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Article Abstract
The reagent system based on the combined use of EtSiH/I acts as an efficient -glycosidation promoter for the synthesis of natural and sugar-modified nucleosides. An analysis of reaction stereoselectivity in the absence of C2-positioned stereodirecting groups revealed high selectivity with six-membered substrates, depending on the nucleophilic character of the nucleobase or based on anomerization reactions. The synthetic utility of the EtSiH/I-mediated -glycosidation reaction was highlighted by its use in the synthesis of the investigational drug apricitabine.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11354600 | PMC |
| http://dx.doi.org/10.3390/ijms25169030 | DOI Listing |
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