Synthesis of Natural and Sugar-Modified Nucleosides Using the Iodine/Triethylsilane System as -Glycosidation Promoter.

The reagent system based on the combined use of EtSiH/I acts as an efficient -glycosidation promoter for the synthesis of natural and sugar-modified nucleosides. An analysis of reaction stereoselectivity in the absence of C2-positioned stereodirecting groups revealed high selectivity with six-membered substrates, depending on the nucleophilic character of the nucleobase or based on anomerization reactions. The synthetic utility of the EtSiH/I-mediated -glycosidation reaction was highlighted by its use in the synthesis of the investigational drug apricitabine.

Screen Printed Based Impedimetric Immunosensor for Rapid Detection of in Drinking Water.

The development of a simple and low cost electrochemical impedance immunosensor based on screen printed gold electrode for rapid detection of in water is reported. The immunosensor is fabricated by immobilizing anti- antibodies onto a gold surface in a covalent way by the photochemical immobilization technique, a simple procedure able to bind antibodies upright onto gold surfaces. Impedance spectra are recorded in 0.

QCM-based immunosensor for rapid detection of Salmonella Typhimurium in food.

Salmonella Typhimurium is one of the main causes of outbreaks and sporadic cases of human gastroenteritis. At present, the rapid detection of this pathogen is a major goal of biosensing technology applied to food safety. In fact, ISO standardized culture method takes up to ten days to provide a reliable response.

Phosphate-Linked Silibinin Dimers (PLSd): New Promising Modified Metabolites.

By exploiting the regioselective protection of the hydroxyl groups of silibinin along with the well-known phosphoramidite chemistry, we have developed an efficient strategy for the synthesis of new silibinin-modified species, which we have named Phosphate-Linked Silibinin Dimers (PLSd), in which the monomer units are linked by phosphodiester bonds. The antioxidant abilities of the new PLSd were estimated on HepG2 cells using DPPH free radical scavenging and xanthine/xanthine oxidase assays. The new phosphate-metabolites showed a higher anti-oxidant activity than the silibinin, as well as very low toxicity.