Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11361774 | PMC |
| http://dx.doi.org/10.4070/kcj.2024.0195 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Applications of Federated Large Language Model for Adverse Drug Reactions Prediction: Scoping Review.
J Med Internet Res
September 2025
Department of Information Systems and Cybersecurity, The University of Texas at San Antonio, 1 UTSA Circle, San Antonio, TX, 78249, United States, 1 (210) 458-6300.
Background: Adverse drug reactions (ADR) present significant challenges in health care, where early prevention is vital for effective treatment and patient safety. Traditional supervised learning methods struggle to address heterogeneous health care data due to their unstructured nature, regulatory constraints, and restricted access to sensitive personal identifiable information.
Objective: This review aims to explore the potential of federated learning (FL) combined with natural language processing and large language models (LLMs) to enhance ADR prediction.
Identification and antiviral mechanism of a novel chicken-derived interferon-related antiviral protein targeting PRDX1.
PLoS Pathog
September 2025
Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, State Key Laboratory of Pathogen and Biosecurity, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, China.
In this study, we identified a new chicken-specific protein, named chicken interferon-related antiviral protein (chIRAP) after sequence analysis and comparison, which inhibited the proliferation of various viruses including influenza A virus (IAV) and Newcastle Disease Virus (NDV) in vitro, and chicken embryos with high expression of chIRAP reduced IAV infection. Mass spectrometry analysis of chIRAP interacting proteins and screening of interacting proteins affecting the function of chIRAP revealed that the deletion of endogenous chicken peroxiredoxin 1 (chPRDX1) significantly reduced the antiviral effect of chIRAP. In order to clarify the functional site of chPRDX1 affecting the antiviral effect of chIRAP, we constructed the point mutants of chPRDX1 based on the results of molecular docking (D79A, T90A, K93A, Q94A, R110A, R123A), and screened the sites affecting the antiviral effects of chIRAP by knockdown of endogenous chPRDX1 combined with the overexpression mutant strategy, the results showed that the mutations in the sites affected the antiviral effects of chIRAP to different degrees, with D79A being the most significant, and the D79A mutation of chPRDX1 reduces the ability of chPRDX1 to regulate reactive oxygen species (ROS).
View Article and Find Full Text PDFPulmonary Function in Early-Onset Scoliosis: A Literature Review.
JBJS Rev
September 2025
Seattle Children's Hospital, Seattle, Washington.
» Early-onset scoliosis (EOS) causes restrictive lung disease, secondary to deformation of the thoracic cavity, stiffening of the chest wall, and weakening of the respiratory muscles.» Early spinal fusion has been shown to limit thoracic growth and be associated with poor pulmonary outcomes. This has led to the rise of growth-friendly surgical techniques to maximize thoracic growth.
View Article and Find Full Text PDFThe Ordos Basin's Hangjinqi Shiligahan west zone Xiashihezi Formation 1 Member gas reservoir exhibits significant exploration and development potential. However, its sedimentation and reservoir characteristics are poorly understood. To address this, geological, seismic, macroscopic, and microscopic methods are combined.
View Article and Find Full Text PDFExploration of the decontamination of common nonmetallic materials by Ce(IV)/HNO3.
PLoS One
September 2025
School of Nuclear Science and Technology, University of South China Hengyang, Hunan, China.
With the rapid development of the nuclear medicine business worldwide, the removal of iodine-131 from specific contaminated environments to protect public health has important application prospects. In this study, the surface decontamination mechanism of Ce(IV)/HNO3 as a decontaminant for iodine-131-contaminated nonmetallic materials was investigated by using an orthogonal experimental method and scanning electron microscopy (SEM). During the preparation experiments with the contaminated materials, both quartz glass and ceramics reached peak activity concentration levels at 4 h of adsorption (contamination) by using immersion; the decontamination factor (DF) was selected as the test index for the decontamination experiments.
View Article and Find Full Text PDF