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Background: Leukemia is the fifth most common cancer in Saudi Arabia. The aim of this study was to assess the various patterns of leukemia associated with age, gender, and nationality in this region.
Methods: This cross-sectional study was conducted at the regional laboratory in Makkah, Saudi Arabia, from April to November 2023. Descriptive statistics were presented as frequencies and percentages by using the GraphPad Prism software.
Results: This study included 107 patients, and the results showed that leukemia cases were higher in males than females and more prevalent in older patients (above 50 years of age). Overall, acute myeloid leukemia (AML) and acute lymphocytic leukemia (ALL) were the most common types of leukemia among Saudi patients. In addition, AML was the most prevalent type of leukemia in males and females, followed by ALL. Data also revealed that ALL was the most common type in the younger population, whereas AML was highly prevalent in older patients.
Conclusions: In conclusion, this study provides valuable information about the patterns of leukemia reported at the regional laboratory in Makkah and will help in designing management and preventive approaches for these patients. This epidemiological investigation is also valuable for establishing proper medical databases.
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http://dx.doi.org/10.7754/Clin.Lab.2024.240210 | DOI Listing |
Hematology
December 2025
Department of Pediatrics, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, People's Republic of China.
Background: Childhood leukaemia remains a major global health challenge and its impact varies significantly by region. Understanding the patterns of incidence, mortality, prevalence, and disability-adjusted life years (DALYs) is crucial for crafting effective public health initiatives and enhancing care outcomes, especially in regions with constrained resources.
Methods: This study evaluates the worldwide, regional, and country-specific effects of childhood leukemia between 1990 and 2021, leveraging data from the Global Burden of Disease (GBD) initiative.
Ann Med
December 2025
Department of Urology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Background: This study provides a comprehensive analysis of the global, regional, and national epidemiology of acute myeloid leukemia (AML) from 1990 to 2021, focusing on incidence, mortality, and disability-adjusted life years (DALYs).
Methods: Using data from the Global Burden of Disease (GBD) study, we investigated the trends and patterns of AML across 204 countries and territories during 1990 to 2021. All statistical analyses and data visualizations were performed using R (version 4.
JCO Glob Oncol
May 2025
Department of Medical Oncology, Dr B.R.A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India.
Purpose: Gender bias against girls may affect health-seeking behavior and outcomes of childhood cancer. This study aimed to study the nature and extent of gender bias in health care among caregivers of childhood patients with cancer and also in community.
Methods: This cross-sectional mixed-methods study was conducted in a tertiary cancer hospital and an urban community between July 2021 and July 2023.
JAMA Netw Open
September 2025
Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Importance: Patients with advanced cancer frequently receive broad-spectrum antibiotics, but changing use patterns across the end-of-life trajectory remain poorly understood.
Objective: To describe the patterns of broad-spectrum antibiotic use across defined end-of-life intervals in patients with advanced cancer.
Design, Setting, And Participants: This nationwide, population-based, retrospective cohort study used data from the South Korean National Health Insurance Service database to examine broad-spectrum antibiotic use among patients with advanced cancer who died between July 1, 2002, and December 31, 2021.
Background: The white cell precursor (WPC) channel of the Sysmex XN-series hematology analyzer, which is designed for blast detection, showed reduced sensitivity for blast detection in leukopenic patients undergoing chemotherapy. This study aimed to evaluate the gating region for apoptotic blasts in the WPC scattergram to enhance detection sensitivity.
Methods: NOMO-1 cells, a human acute monoblastic leukemia cell line, were treated with varying concentrations of cytarabine (0, 100, 500, and 1,000 nM) for three days to induce apoptosis.