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Background In Australia, syphilis notifications increased 2.5-fold during 2013-2022 and 83 congenital syphilis cases were reported. Timely diagnosis and management are crucial. We developed a tool to promote syphilis testing into our existing 'Future Health Today' (FHT) software and explored its acceptability in general practice. Methods Our tool (FHT-syphilis) scans electronic medical record data to identify and prompt testing for pregnant women, and, people recently tested for sexually transmissible infection (STI) or HIV, but not syphilis. It links to relevant guidelines and patient resources. We implemented FHT-syphilis in 52 general practices using FHT for other conditions and interviewed practice clinicians (n =9) to explore it's acceptability. Data were analysed deductively guided by the Theoretical Framework of Acceptability. Results Interviewees considered syphilis an important infection to focus on and broadly viewed FHT-syphilis as acceptable for identifying patients and giving clinicians authority to discuss syphilis testing. Time constraints and unrelated reasons for a patient's visit were barriers to initiating syphilis testing discussions. Australian STI guidelines were considered appropriate to link to. Some interviewees considered prompts should be based on sexual behaviour, however this is not well captured in the electonic medical record. Two interviewees were alerted to updated Australian STI guidelines via their interaction with FHT-syphilis and expanded their syphilis testing practices. Expertise to initiate discussions about syphilis and risk was deemed important. Conclusions A digital tool for prompting syphilis testing was acceptable to clinicians already using FHT. Linkage to STI guidelines alerted some end-users to updated guidelines, informing STI testing practices.
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http://dx.doi.org/10.1071/SH24097 | DOI Listing |
Commun Dis Intell (2018)
February 2025
Communicable Disease Control Branch, SA Health, Adelaide, South Australia, Australia; Adelaide Sexual Health Centre, Central Adelaide Local Health Network, Adelaide, South Australia, Australia; Royal Adelaide Hospital, Central Adelaide Local Health Network, Adelaide, South Australia, Australia.
Background: Both injecting drug use (IDU) and drug use by non-injecting routes only (non-IDU) are recognised internationally as behavioural risk factors for syphilis. In Australia, this association has predominantly been assessed in sexual health services. To generate evidence supporting regular screening and timely symptomatic testing of all at-risk populations, South Australia in 2022 commenced routine collection of drug use information for statutory syphilis surveillance.
View Article and Find Full Text PDFCommun Dis Intell (2018)
February 2025
Microbiology Department, Territory Pathology, Royal Darwin Hospital, Darwin, Australia.
Congenital syphilis is a preventable yet severe condition resulting from untreated maternal syphilis. Since 2016, Australia has recorded over 95 congenital syphilis cases, with 31/95 (33%) associated with perinatal death. Syphilis serology is complex and therefore performed in designated central laboratories.
View Article and Find Full Text PDFOcul Immunol Inflamm
September 2025
National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA.
Purpose: To report pyramidal-like, hyperreflective changes of the outer retina and retinal pigmented epithelium (RPE) in three patients with an atypical non-syphilitic outer retinopathy.
Study Design/materials And Methods: Single institutional case series conducted at the National Eye Institute, National Institutes of Health.
Results: Hyperreflective, pyramidal lesions of the outer retina and RPE have been described in patients with syphilitic posterior segment uveitis.
Ocul Immunol Inflamm
September 2025
Manchester Royal Eye Hospital, Manchester University NHS Foundation Trust, Manchester, UK.
Purpose: To report a rare case of bilateral necrotising retinitis caused by a potentially novel human adenovirus D (HAdV-D) in a post-bone marrow transplant patient and to highlight the diagnostic challenges and therapeutic role of intravenous cidofovir, alongside a review of previously reported cases of human adenovirus (HAdV) retinitis.
Methods: Retrospective case report.
Results: A 60-year-old man with a history of acute myeloid leukaemia, in remission post-bone marrow transplant, presented with bilateral hypertensive granulomatous panuveitis and necrotising retinitis.
medRxiv
August 2025
Infectious Diseases Institute, Makerere University, Kampala, Uganda.
Introduction: In Uganda, the spatial distribution of syphilis varies by age, gender, and region. Identifying clusters (subsets of administrative subdivisions) with high syphilis prevalence could boost efforts to eliminate mother-to-child transmission of syphilis. We examined spatial variations and clustering of syphilis prevalence among pregnant young women in Central Uganda.
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