98%
921
2 minutes
20
Sugars are vital biomolecules widely found in nature, playing an indispensable role in a plethora of biological processes. Similarly, coumarins are heterocycles with an effective pharmacophore skeleton, making them crucial in drug design and development. Coupling carbohydrate moieties to the small biologically active molecules creates a vast library of glycoconjugates with impressive structural diversity. The potential of coumarin glycosides is being extensively explored due to their broad spectrum of applications, including antibacterial, anticancer, and anticoagulant properties, etc. This review highlights various chemical methodologies for synthesizing diverse coumarin glycohybrids with distinct linkages and explores their immense biological potential, making a significant contribution to the field of organic synthesis.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.carres.2024.109244 | DOI Listing |
J Exp Biol
September 2025
Institute of Environmental Sciences, Faculty of Biology, Jagiellonian University, Kraków, Poland.
The adverse effects of Western diets (WD), high in both fat and simple sugars, which contribute to obesity and related disorders, have been extensively studied in laboratory rodents, but not in non-laboratory animals, which limits the scope of conclusions. Unlike laboratory mice or rats, non-laboratory rodents that reduce body mass for winter do not become obese when fed a high-fat diet. However, it is not known whether these rodents are also resistant to the adverse effects of WD.
View Article and Find Full Text PDFF1000Res
September 2025
Institute of Food and Biotechnology, Can Tho University, Can Tho City, Vietnam.
Background: has been extensively studied for its bioactive components and medicinal properties. This study was carried out to evaluate the fermentation ability of 2.1 yeast to determine suitable fermentation conditions.
View Article and Find Full Text PDFChembiochem
September 2025
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (Leibniz-HKI), Beutenbergstrasse 11a, 07745, Jena, Germany.
Soils harbor some of the most diverse microbiomes on Earth. Interactions within these microbial communities are often mediated by natural products, many functioning as chemical signals. Specialized metabolites known as arginoketides, or arginine-derived polyketides, have been linked to mediate these interactions.
View Article and Find Full Text PDFPlant Cell Environ
September 2025
Department of Landscape Architecture, Zhejiang Sci-Tech University, Hangzhou, China.
Sugar metabolism is commonly implicated as crucial in the transition between growth and cessation during winter; however, its exact role remains elusive. The evergreen iris (Iris japonica) ceases growth in winter without entering endodormancy, yet it continues to sustain sugar metabolism and transport throughout the season. Here, we elucidate the mechanisms underlying the sugar-mediated growth transition-the shift between growth and cessation-in I.
View Article and Find Full Text PDFAnim Sci J
September 2025
Department of Animal Science, Bangladesh Agricultural University, Mymensingh, Bangladesh.
This study investigates the effects of L-carnitine on nuclear maturation and fertilization in cattle and goat oocytes. Ovaries were collected from females with poor reproductive efficiency in the tropical climate, and cumulus-oocyte complexes (COCs) were retrieved from large antral follicles. COCs were cultured with varying concentrations of L-carnitine (0, 0.
View Article and Find Full Text PDF