Diastereoselective Synthesis of -Glycosides via Buchwald-Hartwig Coupling.

Herein we report a practical and highly efficient methodology for the β-selective synthesis of -glycosides via Buchwald-Hartwig coupling. This glycosylation strategy employs glycosyl chloride with different amine aglycones and is catalyzed by an inexpensive copper(I) catalyst under mild, ligand-free conditions. The synthetic applicability is further demonstrated through the gram-scale reaction and the late-stage functionalization of bioactive molecules.

Regioselective O-arylation of 6-hydroxy groups in carbohydrates.

We report an efficient method for regioselective O-arylation of the 6-hydroxy group of carbohydrates. The reaction involves a nucleophilic aromatic substitution reaction (SAr) using electron-deficient arenes under mild conditions. Regioselectively monoarylated carbohydrate derivative was produced smoothly in the reaction by fine-tuning with the base.

Thiourea-catalyzed glycosylation: a breakthrough in stereoselective synthesis of oligosaccharides.

Oligosaccharides are vital biomolecules that play an essential role in various biological functions. For studying biochemical processes, it is essential to have access to pure as well as structurally well-defined oligosaccharides. However, achieving high yields with excellent anomeric stereoselectivity through chemical glycosylation remains a challenging task for chemists.

BBX22 enhances the accumulation of antioxidants to inhibit DNA damage and promotes DNA repair under high UV-B.

Under changing climatic conditions, plant exposure to high-intensity UV-B can be a potential threat to plant health and all plant-derived human requirements, including food. It's crucial to understand how plants respond to high UV-B radiation so that proper measures can be taken to enhance tolerance towards high UV-B stress. We found that BBX22, a B-box protein-coding gene, is strongly induced within one hour of exposure to high-intensity UV-B.

Benzene-1,3-disulfonyl Fluoride Mediated Synthesis of Glycosyl Fluorides from Glycosyl Hemiacetals.

We developed an efficient method for synthesizing glycosyl fluorides from glycosyl hemiacetals using benzene-1,3-disulfonyl fluoride () as the fluorinating agent in combination with the base DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) under mild conditions.

Sugar functionalized coumarin motifs: Synthesis and applications.

Sugars are vital biomolecules widely found in nature, playing an indispensable role in a plethora of biological processes. Similarly, coumarins are heterocycles with an effective pharmacophore skeleton, making them crucial in drug design and development. Coupling carbohydrate moieties to the small biologically active molecules creates a vast library of glycoconjugates with impressive structural diversity.

Interplay of light and abscisic acid signaling to modulate plant development.

Exogenous light cues and the phytohormone abscisic acid (ABA) regulate several aspects of plant growth and development. In recent years, the role of crosstalk between the light and ABA signaling pathways in regulating different physiological processes has become increasingly evident. This includes regulation of germination and early seedling development, control of stomatal development and conductance, growth, and development of roots, buds, and branches, and regulation of flowering.

Integration of light and ABA signaling pathways to combat drought stress in plants.

Drought is one of the most critical stresses, which causes an enormous reduction in crop yield. Plants develop various strategies like drought escape, drought avoidance, and drought tolerance to cope with the reduced availability of water during drought. Plants adopt several morphological and biochemical modifications to fine-tune their water-use efficiency to alleviate drought stress.

Plant microProteins: Small but powerful modulators of plant development.

MicroProteins (miPs) are small and single-domain containing proteins of less than 20 kDa. This domain allows microProteins to interact with compatible domains of evolutionary-related proteins and fine-tuning the key physiological pathways in several organisms. Since the first report of a microProtein in mice, numerous microProteins have been identified in plants by computational approaches.