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Article Abstract
We report an efficient method for regioselective O-arylation of the 6-hydroxy group of carbohydrates. The reaction involves a nucleophilic aromatic substitution reaction (SAr) using electron-deficient arenes under mild conditions. Regioselectively monoarylated carbohydrate derivative was produced smoothly in the reaction by fine-tuning with the base. The pentafluoropyridine (P1) in combination with N, N-diisopropylethylamine (DIPEA) was successfully converted to regioselective O-arylated products of different positional hydroxy group free sugar derivatives with various functional groups.
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| http://dx.doi.org/10.1016/j.carres.2025.109447 | DOI Listing |
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