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Purpose: To report the clinical features and outcomes in eyes that underwent vitreoretinal surgery for complications of concurrent sickle cell retinopathy and diabetic retinopathy.
Methods: Retrospective, consecutive case series of all eyes that underwent vitreoretinal surgery for complications secondary to concurrent sickle cell retinopathy and diabetic retinopathy between January 01, 2014, and December 31, 2021.
Results: The study included 20 eyes of 14 patients. Indications for surgery included tractional retinal detachment in 12 eyes (60%), combined tractional retinal detachment/rhegmatogenous retinal detachment in 6 eyes (30%), and vitreous hemorrhage in 2 eyes (10%). Pars plana vitrectomy was performed in all eyes. One eye received a scleral buckle at the same time as pars plana vitrectomy. There was no change in mean best-corrected visual acuity at the last follow-up examination (1.5 [20/678]) when compared with mean preoperative best-corrected visual acuity (1.6 [20/762], P = 0.83). Preoperative best-corrected visual acuity correlated with postoperative best-corrected visual acuity at the last follow-up examination in eyes with retinal detachment (r = 0.49, P = 0.04). Single operation anatomic success was achieved in 11 of 17 eyes (65%) with retinal detachment.
Conclusion: Functional and anatomic outcomes after surgery in eyes with concurrent sickle cell retinopathy and diabetic retinopathy are relatively poor.
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http://dx.doi.org/10.1097/IAE.0000000000004156 | DOI Listing |
Hemoglobin
July 2025
Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Backgound: Induction of fetal hemoglobin (HbF; α2γ2) production can alleviate the clinical severity of sickle cell disease (SCD) and β-thalassemia. SNPs (e.g.
View Article and Find Full Text PDFEmerg Med Clin North Am
August 2025
Virginia Tech Carilion School of Medicine, Roanoke, VA, USA. Electronic address:
Despite advances in outpatient treatment options, early mortality, chronic pain, and limitations in quality-of-life indices remain substantial for those living with SCD. It is imperative for emergency providers (EPs) to understand their challenging and dual obligation when treating a patient with SCD. First, the EP must aggressively manage the acute pain episode in an objective manner.
View Article and Find Full Text PDFJ Investig Med High Impact Case Rep
May 2025
University of Miami Health System (UHealth), Miami, FL, USA.
Hyperammonemia syndrome and posterior reversible encephalopathy syndrome (PRES) are potentially devastating diagnoses in transplant patients. Their underlying etiologies and pathophysiologies remain incompletely understood, and while they are separately well-documented complications in posttransplant patients, they have not been described concurrently. Here we present a case of both hyperammonemia syndrome and PRES causing rapid mental status decline in a 31-year-old bone marrow transplant recipient.
View Article and Find Full Text PDFTransfusion
May 2025
Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
Background: Measurement of transfused red blood cell (RBC) survival is relevant to the effective management of sickle cell disease (SCD). Following amustaline/glutathione pathogen-reduced (PR) RBC transfusion, small quantities of PR-RBC surface-bound acridine are detectable by flow cytometry. Concurrent biotin labeling was used to validate the acridine marker and track transfused PR-RBCs in SCD.
View Article and Find Full Text PDFHemoglobin
May 2025
Caribbean Institute for Health Research - Sickle Cell Unit, The University of the West Indies Mona Campus, Kingston 7, Jamaica.
Vaso-occlusive crisis (VOC) pain episodes often occur with menses and concurrent hormonal contraceptive use may reduce their frequency. This study tested the hypothesis that among women with sickle cell disease (SCD), sex hormones are associated with pain detection thresholds. Women with SCD aged minimum 18 years with regular menses, and without acute illnesses, pregnancy, oophorectomy, or hormonal contraceptive use within three months prior were included.
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