Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Purpose: Currently there is no generally accepted standardized approach for the pathological evaluation of soft tissue sarcoma (STS) histology appearance after preoperative radiotherapy (PORT). This study aimed to investigate the prognostic value of pathological appearance after PORT for patients with high-grade limb/trunk STS.
Methods: A cohort of 116 patients with high-grade STS of the limb/trunk treated with PORT followed by resection were evaluated. Patient characteristics, imaging tumor morphology (size, volume), and histopathology (mitotic and necrosis rate, viable cell, hyalinization/fibrosis cytopathic effect) were reviewed and reassessed. Disease free survival (DFS) and overall survival (OS) were calculated using the Kaplan-Meier method, and the hazard ratio was derived from Cox proportional hazard models. Two predictive nomograms were calculated based on significant predictors identified.
Results: The 5-year DFS and OS were 52.9% and 70.3%, respectively. Tumor size before (HR:1.07, 95%CI: 1.01-1.14) and after PORT (HR:1.08, 95%CI: 1.01-1.14), tumor volume (HR:1.06, 95%CI: 1.01-1.12), mitotic rate after PORT (HR: 1.06, 95%CI: 1.02-1.11), mitotic rate change after PORT (HR:1.04, 95%CI:1.00-1.09) were independent risk factors for DFS. Tumor size before (HR:1.08, 95%CI: 1.03-1.14) and after PORT (HR:1.09, 95%CI: 1.04-1.15), tumor volume (HR:1.05, 95%CI: 1.01-1.09), mitotic rate after PORT (HR: 1.09, 95%CI: 1.04-1.13), mitotic rate change after PORT (HR:1.05, 95%CI:1.01-1.09) were independent risk factors for OS. The C-index of pathologic predictive nomogram based on mitotic rate for DFS and OS were 0.67 and 0.73, respectively. The C-index of morphology-pathology predictive nomogram for OS was 0.79.
Conclusion: Tumor size before and after PORT, tumor volume, mitotic rate after PORT, mitotic rate change after PORT were independent risk factors for DFS and OS in high-grade STS patients treated with PORT. The mitotic rate, independent of tumor morphology, showed its potential as a prognostic biomarker for pathologic evaluation in patients treated with PORT.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.radonc.2024.110482 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
ChroMOS: a "microwire-like" CMOS neural probe for chronic neural recordings in mice.
Biosens Bioelectron
September 2025
Microtechnology for Neuroelectronics Unit (NetS(3) lab), Fondazione Istituto Italiano di Tecnologia, Genova, Italy.
Achieving stable and continuous monitoring of signals of numerous single neurons in the brain faces the conflicting challenge of increasing the microelectrode count while minimizing cross-sectional shank dimensions to reduce tissue damage, foreign-body-reaction and maintain signal quality. Passive probes need to route each microelectrode individually to external electronics, thus increasing shank size and tissue-damage as the number of electrodes grows. Active complementary metal-oxide-semiconductor (CMOS) probes overcome the limitation in electrode count and density with on-probe frontend, addressing and multiplexing circuits, but current probes have relatively large shank widths of 70 - 100 μm.
View Article and Find Full Text PDFThe Hox Gene, , controls the size and timely mitotic entry of neural stem cells during CNS patterning in .
Mol Biol Cell
September 2025
Cytogenetics Laboratory, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi-221005.
Cell size is strongly correlated with several biological processes, including the cell cycle and growth. Here, we investigated the regulation of stem cell size during central nervous system (CNS) development and its association with cell fate. We note that neural stem cells (NSCs) in different regions of the ventral nerve cord increase their size at different rates.
View Article and Find Full Text PDFTargeting stem cells with oncolytic viruses: a mathematical modelling approach.
Math Biosci Eng
July 2025
Department of Mathematics and Statistics, University of New Brunswick, Fredericton, NB, Canada.
Intratumoural epigenetic heterogeneity, which affects the outcome of many cancer treatments, results from stem cell-differentiated cell hierarchy. Cancer stem cells, also known as tumour-initiating cells, are a pluripotent subpopulation of tumour cells capable of creating a tumour clone through self-renewal and differentiation. Oncolytic viral therapy is a category of cancer therapeutics with high specificity in targeting cancer cells while leaving normal cells unharmed.
View Article and Find Full Text PDFClinical, Histopathological, Dermoscopic Features, and , , and Cell Cycle Genes' Mutation Status in Cutaneous Melanoma.
Cancers (Basel)
August 2025
Unit of Cancer Genetics, Istituto di Ricerca Genetica e Biomedica-Consiglio Nazionale delle Ricerche (IRGB-CNR), Traversa La Crucca 3, 07100 Sassari, Italy.
: The clinical, histopathological, and dermoscopic features may be associated with melanoma mutational status. The aims of the study were to assess the clinical, histopathological, and dermoscopic features of melanoma to identify their correlation with , , and cell cycle genes' mutational status in melanoma. : The clinical, histopathological information, dermoscopic images, and genomic DNA of 55 histopathologically diagnosed primary cutaneous melanomas were retrospectively analyzed.
View Article and Find Full Text PDFCRTC1::TRIM11 Cutaneous Tumor Mimicking Primary Dermal Melanoma: Case Report With Literature Review.
Am J Dermatopathol
August 2025
Department of Dermatology, University of Pennsylvania, Philadelphia, PA; and.
CRTC1::TRIM11 cutaneous tumor (CTCT) is a newly identified dermal amelanotic tumor that shows epithelioid to spindle cell morphology with melanocytic differentiation and harbors an in-frame translocation, CRTC1::TRIM11. Given the limited number of reported cases describing its biologic behavior, it is crucial to distinguish this entity from histopathologic mimics, including clear cell sarcoma and metastatic or primary dermal melanoma. Herein, we report a 39-year-old woman with CTCT on the left leg histopathologically mimicking dermal melanoma.
View Article and Find Full Text PDF