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http://dx.doi.org/10.1016/j.ajp.2024.104166 | DOI Listing |
J Neural Transm (Vienna)
September 2025
Parkinson's Foundation Centre of Excellence, King's College Hospital, Denmark Hill, London, SE5 9RS, UK.
Parkinson's disease patients are at increased risk of road traffic and car accidents and those with excessive daytime sleepiness are specially susceptible. Abnormal scores on the Epworth Sleepiness Scale predicts risk for driving-related somnolence which may cause road traffic accidents in driving patients as many such patients declare dozing of while in a car. Our study estimates that over 40% of patients with daytime somnolence have risks of dozing off in a car.
View Article and Find Full Text PDFAm J Geriatr Psychiatry
August 2025
Department of Psychiatry (MLO, SEC, JZ, KS), Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands; Neuroimmunology Research Group (KS), Netherlands Institute for Neuroscience, Amsterdam, The Netherlands; Psychiatric Program of the Netherlands Brain Bank (KS), Ne
Parkinson's disease (PD) is characterized by two neurobiological markers: pathological α-synuclein and/or a dopaminergic deficit. Depression is common in PD, and may precede motor signs, particularly in late-onset depression (LOD). We conducted two systematic reviews and a meta-analysis to examine the relationship between depression and PD development.
View Article and Find Full Text PDFJ Affect Disord
September 2025
Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Department of Neurology, Yale University, New Haven, CT, USA. Electronic address:
Purpose: Dopamine is a neurotransmitter implicated in functions ranging from motor control to cognitive performance. In humans, dopaminergic markers have been associated with seasonal symptomatic fluctuations. Here we investigated potential seasonal variations in dopamine D2/D3 receptor availability in healthy adults using [C]PHNO positron emission tomography (PET) imaging.
View Article and Find Full Text PDFInt Dent J
September 2025
Center of Excellence in Precision Medicine and Digital Health, Geriatric Dentistry and Special Patients Care International Program, Department of Physiology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand; Clinic of General - Special Care and Geriatric Dentistry, Center for Dental
Background: Emerging evidence suggests a link between the oral microbiome and autism spectrum disorder (ASD), a neurodevelopmental condition characterised by social and behavioural impairments. The vast microbial reservoirs in the gut complement those of the oral cavity, suggesting a potential oral-gut-brain axis that may influence ASD and perhaps other neurological diseases, such as Parkinson's syndrome and Alzheimer's disease. For the first time, this systematic review synthesises the current knowledge of oral microbiome composition, diversity, and functionality in ASD and its potential diagnostic and therapeutic implications.
View Article and Find Full Text PDFDrug Alcohol Depend
August 2025
Center for Substance Abuse Research and Department of Neural Sciences, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, Philadelphia, PA 19140, USA. Electronic address:
Background: The use of methamphetamine has continued to rise in the US. In addition to facilitating dopamine neurotransmission, methamphetamine indirectly increases glutamate release, which activates N-methyl-D-aspartate receptors (NMDARs). Ketamine is a noncompetitive NMDAR antagonist.
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