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Prolactinomas are a common cause of infertility in women. Medical treatment with dopamine agonists (DAs) has an excellent efficacy at restoring fertility and a reassuring safety profile in early pregnancy. Surgical treatment before conception is required in some cases of large macroadenomas and incomplete treatment response. In women with microprolactinomas, the pregnancy course is usually uneventful. In women with macroprolactinomas that are near/abut the optic chiasm, symptomatic tumor enlargement can occur during pregnancy and require a multidisciplinary team approach. This review provides an update regarding outcomes and management of prolactinomas before conception, during pregnancy, and postpartum.
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http://dx.doi.org/10.1016/j.ecl.2024.05.004 | DOI Listing |
Ann Intern Med
September 2025
Department of Medicine, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (J.G.R.).
Background: Animal studies show ovarian follicle damage and mutagenesis after ionizing radiation exposure. Computed tomography (CT) imaging is commonly done outside pregnancy, but risks to future pregnancy are unknown.
Objective: To evaluate the risk for spontaneous pregnancy loss and congenital anomalies in offspring of women exposed to CT ionizing radiation before conception.
Ann Intern Med
September 2025
Associate Professor of Radiology, Penn State Health, Hershey, Pennsylvania.
Rev Esc Enferm USP
September 2025
Universidade de São Paulo, Escola de Enfermagem, São Paulo, SP, Brazil.
Objective: To identify pregnant women with urinary tract infections who are being monitored at a primary health care unit and their knowledge about antibiotics, as well as facilitating and challenging factors perceived by nurses that influence care, with a focus on antimicrobial resistance.
Method: Exploratory, descriptive study with a quantitative approach, involving pregnant women with urinary tract infections undergoing antibiotic treatment at a municipal health unit in São Paulo and nurses working at the same location. Data were obtained from computerized systems, medical records, and interviews, and were synthesized and analyzed using Microsoft Excel and Stata software.
PLoS One
September 2025
Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States.
Background: Maternal childhood maltreatment has been associated with higher risk of adverse neurodevelopment in offspring. Chronic systemic inflammation has been associated with childhood maltreatment and has been identified as a gestational risk factor for adverse neurodevelopment in offspring. Thus, inflammation may be a mechanism by which maternal exposure to maltreatment affects offspring neurodevelopment.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Health and Life Cycles, School of Public Health, University of São Paulo, São Paulo, Brazil.
Studies have shown that excessive obstetric interventions such as induced labor and caesarean sections have contributed to the shortening of the length of gestation, leading to a left shift in gestational age (GA) at birth. The aim of this study was to analyze trends in GA and the contribution of associated factors to changes in São Paulo city, Brazil during the period 2012-2019. We conducted an observational time-series study of births in São Paulo using data from Brazil's national live births information system (SINASC).
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