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This retrospective clinical study was designed to examine the predictive value of thromboelastography (TEG) combined with coagulation function for venous thromboembolism (VTE) in hospitalized patients with cancer. Among 215 patients admitted between May 2020 and January 2022, 39 (18.14%) were diagnosed with VTE during hospitalization. Significant differences were found in D-dimer, ATIII and TEG parameters (maximum amplitude and coagulation index) between VTE-positive and VTE-negative patients (p < 0.05). Multivariate analysis revealed tumor node metastasis stage, concomitant infection, smoking history and D-dimer as independently associated with VTE. The constructed model and D-dimer areas under the curve were 0.809 and 0.764, respectively. TEG parameters were not significantly predictive indicators for VTE, with D-dimer remaining a key predictor.
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http://dx.doi.org/10.1080/17520363.2024.2342239 | DOI Listing |
Cureus
August 2025
Spinal Surgery, Royal National Orthopaedic Hospital, London, GBR.
Background: Venous thromboembolism (VTE) is a preventable complication following orthopaedic surgery. While most guidelines focus on arthroplasty, a significant number of knee surgeries fall under non-arthroplasty procedures, where post-operative VTE prophylaxis recommendations vary depending on anaesthetic time and weight-bearing status. National guidelines and available literature suggest the use of VTE prophylaxis for these cases, yet adherence in clinical practice remains inconsistent.
View Article and Find Full Text PDFCureus
August 2025
Vascular Surgery, University Hospitals of Leicester NHS Trust, Leicester, GBR.
Background Fasting during the month of Ramadan is practiced by over a billion Muslims worldwide. This religious observance, which involves complete abstention from food and fluids during daylight hours, may contribute to dehydration and increase the risk of venous thromboembolism (VTE), particularly in hot climates. Despite this theoretical concern, limited clinical evidence exists on the actual incidence and risk of VTE associated with prolonged fasting.
View Article and Find Full Text PDFFront Pediatr
August 2025
Division of Pediatric Intensive Care, Department of Pediatrics, Ankara University Faculty of Medicine, Ankara, Türkiye.
Objective: Catheter-related thrombosis is a common complication of central venous catheter insertion. As the use of central venous catheters increases in pediatric critical care settings, catheter-related thrombosis is becoming more common among patients who typically have multiple risk factors for thromboembolism. We aimed to investigate impact of catheter-to-vein diameter ratio on thrombosis in pediatric central venous catheterization.
View Article and Find Full Text PDFRes Pract Thromb Haemost
July 2025
Division of Cardiology, Ahmanson-UCLA Cardiomyopathy Center, University of California Los Angeles, Los Angeles, California, USA.
Background: Venous thromboembolism (VTE) is a major cause of cardiovascular morbidity and mortality globally. Although direct oral anticoagulants (DOACs) have improved extended VTE treatment, the optimal dose for balancing efficacy and safety remains unclear.
Objectives: This systematic review and meta-analysis aimed to evaluate the efficacy and safety of reduced-dose DOACs vs full-dose regimens during extended anticoagulation for VTE.
Cardiol Cardiovasc Med
August 2025
Department of Translational Research, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, California 91766 USA.
Deep vein thrombosis (DVT) and pulmonary embolism (PE) are key initiating events in the development of venous thromboembolism (VTE), a condition associated with significant morbidity, mortality, and long-term complications. While traditional therapies have focused on anticoagulation and thrombolysis, current evidence describes the pivotal role of immune pathways in the pathogenesis and progression of thrombosis. This review explores the multifaceted mechanisms underlying DVT and PE, emphasizing the contribution of inflammation, leukocyte activation, and immuno-thrombosis to thrombus formation and embolization.
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