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The most commonly applied way of teaching students to convey the foundations of human anatomy and physiology involves textbooks and lectures. This way of transmitting knowledge causes difficulties for students, especially in the context of three-dimensional imaging of organ structures, and as a consequence translates into difficulties with imagining them. Even despite the rapid uptake of knowledge dissemination provided by online materials, including courses and webinars, there is a clear need for learning programs featuring first-hand immersive experiences tailored to suit individual study paces. In this paper, we present an approach to enhance a classical study program by combining multi-modality data and representing them in a Mixed Reality (MR)-based environment. The advantages of the proposed approach have been proven by the conducted investigation of the relationship between atrial anatomy, its electrophysiological characteristics, and resulting P wave morphology on the electrocardiogram (ECG). Another part of the paper focuses on the role of the sinoatrial node in ECG formation, while the MR-based visualization of combined micro-computed tomography (micro-CT) data with non-invasive CineECG imaging demonstrates the educational application of these advanced technologies for teaching cardiac anatomy and ECG correlations.
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http://dx.doi.org/10.3389/fmed.2024.1422017 | DOI Listing |
Catheter Cardiovasc Interv
September 2025
IRCCS Humanitas Research Hospital, Rozzano-Milan, Italy.
Background: Given the divergence in recommendations regarding the relevance of inducible ischemia regarding the indication to revascularize chronic total occlusions (CTOs) among European and North American guidelines, we aim at investigating the prevalence and the prognostic impact of significant inducible ischemia in an unselected cohort of asymptomatic CTO patients, integrating collateralization status and viability assessment with stress cardiac magnetic resonance (CMR).
Methods: From a cohort of 749 patients referred to our center with a diagnosis of CTO, we retrospectively analyzed 111 asymptomatic individuals who underwent an adenosine stress CMR. The amount of inducible ischemia subtended by the CTO was calculated, as well as the presence of viable myocardium and the collateralization status.
Nan Fang Yi Ke Da Xue Xue Bao
August 2025
Affiliated Hospital of North China University of Science and Technology, Tangshan 063000, China.
Objectives: To investigate the effect of cardiomyocytes-derived exosomes on lipopolysaccharide (LPS)-induced cardiomyocyte injury and its mechanism.
Methods: Exosomes isolated from rat cardiomyocytes with or without LPS treatment were co-cultured with rat lymphocytes. The lymphocytes with or without exosome treatment were co-cultured with LPS-induced rat cardiomyocytes for 48 h.
Food Chem Toxicol
September 2025
Department of Human Anatomy, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria.
Globally, the South Asian Cocktail (SAC), a substance of abuse, is becoming popular. The effects of SAC on male fertility are unknown; however, its component pharmaceuticals, such as codeine, rohypnol, and promethazine, have been linked to male infertility. Thus, this study assessed SAC's influence and putative mechanisms on male fertility among SAC consumers.
View Article and Find Full Text PDFFASEB J
September 2025
Department of Aerospace and Mechanical Engineering, University of Southern California, Los Angeles, California, USA.
Myocardial infarction (MI) is a leading cause of death worldwide and the most common precursor to heart failure, even after initial treatment. Precise evaluation of myocardial injury is crucial for assessing interventions and improving outcomes. Extensive evidence from both preclinical models and clinical studies demonstrates that the extent and severity of myocardial injury (i.
View Article and Find Full Text PDFInnovations (Phila)
September 2025
Section of Cardiac Surgery, Department of Surgery, University of Chicago, IL, USA.
Objective: Port sites are a common source of perioperative bleeding in robotic cardiac surgery, which can be exacerbated by patient anatomy and anticoagulation. We present results from the liberal usage of a balloon-tipped coudé catheter for tamponade of robotic port sites during robotic mitral surgery.
Methods: All patients who underwent robotic mitral valve surgery at our institution from August 2016 to July 2022 were studied ( = 320).