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Article Abstract
Recently, N6-methyladenosine (mA) has aroused widespread discussion in the scientific community as a mode of RNA modification. mA comprises writers, erasers, and readers, which regulates RNA production, nuclear export, and translation and is very important for human health. A large number of studies have found that the regulation of mA is closely related to the occurrence and invasion of tumors, while the homeostasis and function of the tumor microenvironment (TME) determine the occurrence and development of tumors to some extent. TME is composed of a variety of immune cells (T cells, B cells, etc.) and nonimmune cells (tumor-associated mesenchymal stem cells (TA-MSCs), cancer-associated fibroblasts (CAFs), etc.). Current studies suggest that mA is involved in regulating the function of various cells in the TME, thereby affecting tumor progression. In this manuscript, we present the composition of mA and TME, the relationship between mA methylation and characteristic changes in TME, the role of mA methylation in TME, and potential therapeutic strategies to provide new perspectives for better treatment of tumors in clinical work.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11271487 | PMC |
| http://dx.doi.org/10.1038/s41420-024-02092-2 | DOI Listing |
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