Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Tumor-associated macrophages (TAMs), as the most prevalent immune cells in the tumor microenvironment, play a pivotal role in promoting tumor development through various signaling pathways. Herein, we have engineered a Se@ZIF-8 core-satellite nanoassembly to reprogram TAMs, thereby enhancing immunotherapy outcomes. When the nanoassembly reaches the tumor tissue, selenium nanoparticles and Zn are released in response to the acidic tumor microenvironment, resulting in a collaborative effort to promote the production of reactive oxygen species (ROS). The generated ROS, in turn, activate the nuclear factor κB (NF-κB) signaling pathway, driving the repolarization of TAMs from M2-type to M1-type, effectively eliminating cancer cells. Moreover, the nanoassembly can induce the immunogenic death of cancer cells through excess ROS to expose calreticulin and boost macrophage phagocytosis. The Se@ZIF-8 core-satellite nanoassembly provides a potential paradigm for cancer immunotherapy by reversing the immunosuppressive microenvironment.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.nanolett.4c02657 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Core-Satellite Nanoassembly Overcomes Spatial Heterogeneity of Dendric Cell Distribution in Pancreatic Tumors for Effective Chemoimmunotherapy.
ACS Nano
February 2025
Nanomedicine Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Article Synopsis
- Pancreatic cancer treatments face challenges due to a dense extracellular matrix that prevents effective drug and immune response penetration.
- Researchers created a hybrid nanoassembly called PLAF@P/T-PD that responds to internal and external stimuli, designed to enhance drug delivery and immune response in tumors.
- Animal studies show this nanoassembly effectively targets primary and metastatic tumors, indicating its potential to improve treatment outcomes for pancreatic cancer.
Electrostatic Assembly of Gold Nanoclusters in Reverse Emulsion Enabling Nanoassemblies with Tunable Structure and Size for Enhanced NIR-II Fluorescence Imaging.
ACS Nano
November 2024
Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Yong Loo Lin School of Medicine and College of Design and Engineering, National University of Singapore, Singapore, 119074, Singapore.
The precise control of the assembly structure and size of gold nanoclusters (AuNCs) can potentially amplify their near-infrared II (NIR-II) fluorescence imaging and targeting properties. However, the conventional electrostatic assembly of AuNCs and charged molecules faces challenges in balancing the inherent electrostatic repulsions among charged units and regulating the diffusion of assembly units. These difficulties limit precise control over assembly size and structure, along with limited options for coassembled molecules, thereby restricting imaging properties and targeting capability.
View Article and Find Full Text PDFReprogramming Tumor-Associated Macrophages with a Se-Based Core-Satellite Nanoassembly to Enhance Cancer Immunotherapy.
Nano Lett
July 2024
College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal Un
Tumor-associated macrophages (TAMs), as the most prevalent immune cells in the tumor microenvironment, play a pivotal role in promoting tumor development through various signaling pathways. Herein, we have engineered a Se@ZIF-8 core-satellite nanoassembly to reprogram TAMs, thereby enhancing immunotherapy outcomes. When the nanoassembly reaches the tumor tissue, selenium nanoparticles and Zn are released in response to the acidic tumor microenvironment, resulting in a collaborative effort to promote the production of reactive oxygen species (ROS).
View Article and Find Full Text PDFTurkevich syntheses represent a foundational approach for forming colloids of monodisperse gold nanoparticles where the use of these structures as building blocks when forming multicomponent nanoassemblies is pervasive. The core-satellite motif, which is characterized by a central core structure onto which satellite structures are tethered, distinguishes itself in that it can realize numerous plasmonic nanogaps with nanometer scale widths. Established procedures for assembling these multicomponent structures are, to a large extent, empirically driven, time-consuming, difficult to reproduce, and in need of a strong mechanistic underpinning relating to the close-range electrostatic interactions needed to secure satellite structures onto core materials.
View Article and Find Full Text PDFSurface-enhanced Raman scattering nanotag of tunable ZIF-8 shell-encapsulated magnetic core-plasmonic satellites for disentangling chemical enhancement from electromagnetic enhancement.
Nanotechnology
August 2024
Institute of Solid State Physics, HeFei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui 230031, People's Republic of China.
To enhance the stability of Raman reporters, these reporters were trapped in a metal organic framework (MOF) exoskeleton that was grown and compressed on FeO@Au core-satellites, producing recyclable surface-enhanced Raman scattering (SERS) nanotags. Furthermore, encapsulation of Raman reporters in the assembled MOF-based nanocomposites was divided into two types of patterns, pre-enrichment and post-enrichment, in order to disentangle chemical enhancement of charge transfer (CT) from electromagnetic enhancement (EM) in SERS. Hence, to demonstrate the effect of encapsulation, a typical non-thiolated Raman reporter, for example crystal violet (CV) trapped in a core-satellite nanoassembly-based zeolitic imidazolate framework (ZIF-8) shell, was selected.
View Article and Find Full Text PDF