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http://dx.doi.org/10.1186/s40478-024-01825-9 | DOI Listing |
Neurology
September 2025
Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, University of Cambridge, United Kingdom.
Background And Objectives: Cerebrovascular reactivity (CVR) is an indicator of cerebrovascular health, and its signature in familial frontotemporal dementia (FTD) remains unknown. The primary aim was to investigate CVR in genetic FTD using an fMRI index of vascular contractility termed resting-state fluctuation amplitudes (RSFAs) and to assess whether RSFA differences are moderated by age. A secondary aim was to study the relationship between RSFA and cognition.
View Article and Find Full Text PDFJ Neurotrauma
September 2025
Department of Mechanical and Industrial Engineering, University of Illinois Chicago, Chicago, Illinois, USA.
Traumatic brain injury (TBI) is the most important environmental risk factor for neurodegenerative disease. Tauopathy plays an important role in post-traumatic neurodegeneration. Human-induced pluripotent stem cell (hiPSC)-derived cortical organoids have exciting potential to reveal the influence of genotype on post-traumatic neurodegeneration because they permit manipulation of the genome in a human system.
View Article and Find Full Text PDFAlzheimers Dement
September 2025
Talisman Therapeutics, Babraham Research Campus, Cambridge, UK.
Introduction: Mutations in the MAPT gene that are causal for frontotemporal dementia (FTD) lead to mislocalization of tau protein to the neuronal cell body, changing microtubule dynamics to disrupt the nuclear envelope and nucleocytoplasmic transport.
Methods: We report a high content imaging-based phenotypic screen to identify novel small molecules that correct nuclear envelope defects in human neurons expressing the MAPT IVS10+16 mutation causal for FTD.
Results: Screening a 19,786-compound chemical diversity library, we identified > 100 compounds that corrected nuclear membrane defects in MAPT IVS10+16 neurons, with 23 demonstrating robust dose-dependent rescue.
Clin Neurol Neurosurg
October 2025
Department of Psychology, Islamic Azad University of Torbat-e Jam, Mashhad, Iran.
Background: Alzheimer's disease (AD) is characterized by a complex interplay between amyloid-β (Aβ) and tau pathologies, with increasing evidence implicating cerebral blood flow (CBF) alterations as a critical, yet underexplored, contributor to disease progression. This study aimed to investigate the associations between regional CBF and cerebrospinal fluid (CSF) biomarkers- Aβ1-42, total tau (T-Tau), and phosphorylated tau (P-Tau181)-across the AD continuum.
Methods: We conducted a cross-sectional analysis using data from 416 participants enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI), including cognitively normal individuals, patients with mild cognitive impairment (MCI), and those with AD.
Healthcare (Basel)
August 2025
Department of Clinical Psychology, School of Psychology, Complutense University, 28223 Madrid, Spain.
: Positive psychology interventions (PPIs) may enhance well-being in individuals with severe psychiatric conditions (SPCs), yet little is known about individual differences in treatment response. : We conducted a secondary analysis of a single-blind, parallel-group randomized controlled trial. A total of 119 adults receiving outpatient mental health care were randomized to an 11-week multicomponent PPI plus treatment as usual (PPI + TAU) or TAU alone.
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