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Biomass-based alternatives for the manufacturing of bioplastic materials are important aspects of a more sustainable future; their physicochemical properties need to be able to compete with the existing market to establish them as a viable alternative [...].
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http://dx.doi.org/10.3390/polym16131886 | DOI Listing |
Proc Natl Acad Sci U S A
September 2025
School of Medicine, Chongqing University, Chongqing 400044, China.
Engineering functional exosomes represents a cutting-edge approach in biomedicine, holding the promise to transform targeted therapy. However, challenges such as achieving consistent modification and scalability have limited their wider adoption. Herein, we introduce a universal and effective strategy for engineering multifunctional exosomes through cell fusion.
View Article and Find Full Text PDFJ Youth Adolesc
September 2025
Substantive-Methodological Synergy Research Laboratory, Concordia University, Montreal, QB, Canada.
Young adults use a combination of coping strategies to deal with challenges. Yet, limited research has focused on these combinations, as they differ across different profiles of youth and their implications during the major life transitions of emerging adulthood. Addressing this gap, the present longitudinal person-centered study assesses the nature, stability, predictors (stressful life events, sex), and outcomes (affect, attitude toward life, physical symptoms) of coping profiles during this period.
View Article and Find Full Text PDFEur J Nucl Med Mol Imaging
September 2025
Department of Nuclear Medicine, Changhai Hospital, Naval Medical University, 168 Changhai Road, Yang Pu District, Shanghai, 200433, China.
Purpose: In this retrospective study, whether [Ga]Ga-DOTA-FAPI-04 PET/MR imaging biomarkers can predict the progression-free survival (PFS) and overall survival (OS) of patients with advanced pancreatic cancer was investigated.
Methods: Fifty-one patients who underwent [Ga]Ga-DOTA-FAPI-04 PET/MR scans before first-line chemotherapy were recruited. Imaging biomarkers, including the maximum tumor diameter, minimum apparent diffusion coefficient (ADC), maximum and mean standardized uptake values (SUV and SUV), fibroblast activation protein- (FAP-) positive tumor volume (FTV and W-FTV) and total lesion FAP expression (TLF and W-TLF), were recorded for primary and whole-body tumors.
Rev Sci Instrum
September 2025
Key Laboratory for Laser Plasmas (MoE) and School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai, China.
Neutron Time-of-Flight (nTOF) detectors are key diagnostics to detect thermonuclear neutrons in laser-fusion experiments. This diagnostic, however, is often plagued by strong gamma-ray noise prior to neutron signals, especially in harsh fast-ignition (FI) environments. To address this issue, a combination of low-afterglow liquid scintillators with time-gated photomultiplier tubes as necessary nTOF components would be a natural solution.
View Article and Find Full Text PDFNat Prod Rep
September 2025
Saarland University, Department of Pharmacy, Saarbrücken, Germany.
Focus on 2004 to 2024The rediscovery of natural products (NPs) as a critical source of new therapeutics has been greatly advanced by the development of heterologous expression platforms for biosynthetic gene clusters (BGCs). Among these, species have emerged as the most widely used and versatile chassis for expressing complex BGCs from diverse microbial origins. In this review, we provide a comprehensive analysis of over 450 peer-reviewed studies published between 2004 and 2024 that describe the heterologous expression of BGCs in hosts.
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