antifungal activity of biosynthesized selenium nanoparticles using plant extracts and six comparators against clinical strains.

Background And Purpose: species are commonly resistant to many antifungal drugs. The limited therapeutic options available have led to a surge of research efforts aimed at discovering novel antifungal compounds in recent decades. This study aimed to assess the antifungal activity of plant-based biosynthesized selenium nanoparticles (Se NPs) and six comparators against a set of clinical strains.

Materials And Methods: antifungal activity of Se NPs synthesized using plant extracts of , , L. hull, L. hull and , as well as six common antifungal drugs, namely voriconazole, itraconazole, amphotericin B, posaconazole, natamycin, and caspofungin were evaluated against 94 clinical strains using broth microdilution according to Clinical and Laboratory Standards Institute guideline.

Results: The obtained results were intriguing since all five types of biosynthesized Se NPs demonstrated significantly higher antifungal activity, compared to antifungal drugs. It was found that Se NPs synthesized by L. hull extract (0.03 μg/ml) had the lowest geometric mean minimum inhibitory concentration value followed by Se NPs synthesized by  L. hull extract (0.25 μg/ml), extract (0.39 μg/ml), extract (0.55 μg/ml), and extract (0.9 μg/ml).

Conclusion: Plant-based Se NPs demonstrated supreme antifungal activity and could be considered promising antifungal agents for infections. However, tests, such as toxicity and tests are needed before the product can be used in clinical settings.