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http://dx.doi.org/10.1111/imr.13363 | DOI Listing |
Neuromolecular Med
September 2025
Gilgamesh Ahliya University, Baghdad, Iraq.
Autoimmune diseases occur when the immune system mistakenly attacks the body's own tissues, affecting millions of people and often requiring long-term treatment. Current therapies, such as immunosuppressants and biologics, help manage symptoms but can cause serious side effects. A promising new approach involves engineered microbiota-a method that modifies gut bacteria to influence immune function and potentially ease autoimmune conditions.
View Article and Find Full Text PDFNeurosci Appl
August 2025
Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
This scoping review synthesizes emerging evidence on the relationship between gut microbiota and eating disorders (EDs), particularly bulimia nervosa (BN) and binge eating disorder (BED). An electronic search was conducted in the PubMed/MEDLINE and Web of Science databases, spanning from their inception until December 2023. From an initial pool of 166 records, 14 articles were included and qualitatively synthesized.
View Article and Find Full Text PDFEstablishing immune tolerance to gut microbiota and food antigens upon first exposures during early life is essential to prevent inflammatory bowel diseases and food allergy and depends on induction of peripherally induced Rorgt expressing regulatory T (Rorgt+ pTreg) cells. Recent studies have identified a critical role for Rorgt expressing antigen-presenting cells (APC), Thetis cells (TCs), in peripheral regulatory T (pTreg) cell differentiation and tolerance to food and commensal microbes. TCs encompass four distinct subsets, and a subset of TCs, TC IV induces pTreg differentiation, but the transcription factors that control their differentiation are not fully known.
View Article and Find Full Text PDFCureus
August 2025
Medicine, Donesk National Medical University, Donesk, UKR.
Autoimmune diseases (AIDs) are multifaceted, chronic illnesses characterized by immune dysregulation and systemic inflammation. Newer evidence has pointed a finger at the human gut microbiota, a trillion-fold population of microorganisms that inhabits the human GI tract, as a major influential modulator of immune reactivity and a significant contributor to autoimmune pathogenesis. This systematic review will seek to address how the literature correlates with systematic changes in the gut microbiota in AIDs as well as explore mechanistic associations with biological processes like intestinal permeability and modulation of the immune system, coupled with determining the effectiveness of microbiota-directed interventions.
View Article and Find Full Text PDFRecent Adv Antiinfect Drug Discov
September 2025
Guru Gobind Singh College of Pharmacy (135001) Haryana, India.
Rheumatoid arthritis is a chronic autoimmune disease with joint destruction and chronic inflammation symptoms. Conventional therapy focuses on the prevention of the progression of the disease and management of symptoms, rather than curing the disease. Emerging therapies have been developed to cure the disease, which combines conventional therapies with a novel drug delivery system.
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