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Human diseases caused by homozygous PTH1R mutations.
Front Endocrinol (Lausanne)
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Endocrine Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, United States.
The parathyroid hormone receptor type 1 (PTH1R) is a G protein-coupled receptor that mediates the actions of parathyroid hormone (PTH) in the regulation of blood calcium levels, as well as PTH-related protein (PTHrP) in the regulation of skeletal development. Severe loss-of-function homozygous mutations in PTH1R are incompatible with life as in Blomstrand's lethal chondrodysplasia, characterized by accelerated growth plate ossification. More recently, homozygous mutations located in the transmembrane helices, extracellular domains and C-tail of the PTH1R were identified in patients with milder conditions characterized by variable degrees of skeletal and mineral abnormalities.
View Article and Find Full Text PDFMultiquadrant presentation of eruption sequestrum: a case report and literature review.
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September 2025
Xiangya Stomatological Hospital and Xiangya School of Stomatology, Hunan Key Laboratory of Oral Health Research, Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Academician Workstation for Oral-maxilofacial and Regenerative Medicine, Central South University, Changsha, 410008,
Background: Eruption sequestrum (ES) is an uncommon condition characterized by irregular calcified tissues on the occlusal surfaces of erupting permanent molars, primarily in children. Despite its rarity, ES has been linked to potential complications, including gingivitis, occlusal trauma, and delayed tooth eruption.
Case Presentation: This paper reports a multiquadrant ES case affecting the first molars of bilateral maxillary and mandibular arches in a 6-year-old pediatric patient.
Partial cementocyte ablation does not reduce cellular cementum apposition in a mouse model of molar super-eruption.
Bone Rep
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Division of Biosciences, College of Dentistry, The Ohio State University, Columbus, OH, USA.
Cementocytes reside in the cellular cementum of the apical tooth root and resemble bone osteocytes in their markers, lacunocanalicular network, and response to mineralization defects. However, it is unclear if cementocytes have a role in regulating cellular cementum similar to that of osteocytes in controlling bone formation and resorption. The Dmp1Cre-iDTR (Dmp1-DTR) mouse sensitizes -expressing cells, including osteocytes and cementocytes, to diphtheria toxin (DT), allowing selective ablation of cell populations.
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Int Med Case Rep J
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Central Laboratory, Jinan Key Medical and Health Laboratory of Oral Diseases and Tissue Regeneration, Jinan Key Laboratory of Oral Diseases and Tissue Regeneration, Shandong Provincial Key Medical and Health Laboratory of Oral Diseases and Tissue Regeneration, Jinan Stomatological Hospital, Jinan, S
Purpose: Ameloblastic fibroma (AF), an exceedingly rare benign mixed odontogenic tumor, scarcely occurs in the anterior region of the maxilla. This case report aims to delineate the formidable challenges faced during the early diagnosis of such cases, with the ultimate goal of averting missed diagnoses.
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Choosing the Right Extraction Pattern: First Premolars vs. Second Premolars.
Cureus
July 2025
Orthodontics and Dentofacial Orthopedics, Ministry of Health, Riyadh, SAU.
Premolar extraction is a widely used orthodontic intervention to manage crowding, correct malocclusion, and achieve balanced facial aesthetics. Several factors, including the severity of crowding, facial profile requirements, and anchorage demands, influence the choice between extracting first or second premolars. However, this decision is complicated by the distinct impacts each extraction pattern has on tooth movement, soft tissue profile, vertical dimension, and third molar eruption.
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