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Article Abstract
Three previously undescribed and sixteen known alkaloids were bioguidedly isolated from the bulbs of Narcissus tazetta subsp. chinensis (M.Roem.) Masamura & Yanagih. The structures were elucidated by spectroscopic data, including HRESIMS, NMR, and ECD. Eleven of the isolated alkaloids exhibited immunosuppressive activity on the proliferation of human T cells. (+)-Narciclasine (18) showed the most significantly suppressive activity with an IC value of 14 ± 5 nM. In vitro, (+)-narciclasine (18) blocked NF-κB signal transduction, but did not affect PI3K/AKT signal transduction. What was more, (+)-narciclasine significantly reduced ALT and AST levels and alleviated liver damage induced by ConA in AIH mouse model.
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Article Synopsis
- Three new alkaloids and sixteen known alkaloids were identified from the bulbs of Narcissus tazetta subsp. chinensis, with their structures determined using various spectroscopic methods.
- Eleven of these alkaloids were found to have immunosuppressive effects on human T cell proliferation, with (+)-narciclasine showing the strongest activity at an IC value of 14 ± 5 nM.
- In lab studies, (+)-narciclasine inhibited NF-κB signaling but didn’t affect PI3K/AKT signaling, and it also reduced liver damage in a mouse model of autoimmune hepatitis.