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Sesame is an important oilseed crop grown for human consumption in many countries, with a high commercial value due to its high oleic/linoleic acid ratio (O/L ratio). However, its properties may vary among different accessions. In the current study, 282 sesame accessions were evaluated to determine the effects of agronomic traits and genotypes on the O/L ratio. The O/L ratio was positively correlated with the oleic acid (C18:1), stearic acid (C18:0), and myristic acid (C14:0) concentrations, as well as the capsule zone length (CZL), capsule width (CW), and capsule length (CL), and negatively correlated with the linoleic acid (C18:2) and linolenic acid (C18:3) concentrations, the days to maturity (DTM), days to flowering (DTF), and the height of the first capsule-bearing node (HFC) ( < 0.05). In addition, the O/L ratio was affected by the haplotype, as the Hap2 and Hap3 sesame accessions had lower O/L ratios. Therefore, we suggest that the increase and decrease in the contents of C18:1 and C18:2 are associated with the haplotype. A total of 25 agronomic traits and fatty acid compositions were compared via statistical analysis, and accessions with a high O/L ratio were selected. The results of this study can be used as a basis for further research on the development of new sesame varieties through enhancing nutritional functionality.
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http://dx.doi.org/10.3390/plants13121590 | DOI Listing |
Ther Adv Med Oncol
August 2025
National Investigators Group for Ovarian and Breast Cancer Studies, GINEGEPS, Paris, France.
Background: Immune checkpoint inhibitors (ICIs) have shown efficacy in endometrial cancer (EC); however, their efficacy varies according to mismatch repair (MMR) status. Notably, even among patients with MMR-deficient (MMRd) or microsatellite instability-high (MSI-H) tumors, approximately one-third exhibit primary resistance to ICI monotherapy.
Objectives: We aimed to characterize dissimilarities in the tumor immune microenvironment of ICI-treated MMRd/MSI-H versus MMR-proficient (MMRp)/microsatellite stable (MSS) EC, and to identify mechanisms of resistance.
Nat Med
August 2025
Cardiovascular Division, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
In the HELIOS-B randomized clinical trial, the RNA interference therapeutic agent vutrisiran reduced the risk of all-cause mortality and recurrent cardiovascular events among patients with transthyretin amyloidosis with cardiomyopathy (ATTR-CM). In this secondary analysis of HELIOS-B, we evaluated vutrisiran's effects on echocardiographic measures of cardiac structure and function in patients with ATTR-CM receiving vutrisiran or placebo (n = 654, 93% men). At 30 months after treatment, as compared to the placebo group, vutrisiran treatment attenuated increases in mean left ventricular (LV) wall thickness (least squares mean difference: -0.
View Article and Find Full Text PDFERJ Open Res
July 2025
Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden.
Background: While oscillometry appears advantageous over spirometry in detecting peripheral airway dysfunction, a feature of COPD, further research on its role in disease monitoring is needed. The objectives of the present study were to analyse the associations between oscillometry by impulse oscillometry (IOS) and forced oscillation technique (FOT) and airway obstruction, health status, dyspnoea and future exacerbations in COPD.
Methods: Oscillometry and disease burden were assessed in 150 adults with COPD within the Tools Identifying Exacerbations study.
Sci Rep
July 2025
Faculty of Chemistry, University of Wroclaw, Joliot-Curie 14, 50-383, Wroclaw, Poland.
In this research, a green method for the oxidation of benzyl alcohol to its oxidized products has been reported. Firstly, (E)-4-amino-N'-(phenyl(pyridin-2-yl)methylene)benzohydrazide (HL) as an NNO-donor ligand was synthesized by the reaction of 2-benzoylpyridine and 4-aminobenzohydrazide in a molar ratio of 1:1 under reflux condition. HL was used for the synthesis of a V(V) coordination compound, [VO(µ-O)L], through its reaction with NHVO in methanol under reflux condition and the orange crystals of dinuclear oxidovanadium(V) coordination compound, [VO(µ-O)L], were obtained by partial evaporation of the solvent during four days.
View Article and Find Full Text PDFCirc Cardiovasc Imaging
August 2025
Division of Hematology and Oncology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston (M.H.L., G.H.).
Background: Myeloproliferative neoplasms (MPN) are a group of chronic leukemias that are associated with pulmonary hypertension (PH), which has been associated with increased risk adverse outcomes. The echocardiographic characterization of PH in MPN has not been reported, and the prognostic significance of PH among patients with MPN remains unclear.
Methods: This was a multicenter, retrospective cohort study of patients with MPN with ≥1 echocardiogram from 2010 to 2023.