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This research aimed to encapsulate the fruit extract to increase its stability for incorporation into food products such as jelly or jelly powder. After extraction, the nanoliposomes containing the extract were prepared in ratios of 60-0, 50-10, 40-20, and 30-30 lecithin-to-cholesterol. The effects of lecithin-to-cholesterol concentrations on the related parameters were then evaluated. The results showed that the average particle size was in the range of 95.05 to 164.25 nm, and with an increasing cholesterol concentration, the particle size of the nanoliposomes increased. The addition of cholesterol increased the zeta potential from -60.40 to -68.55 millivolt. Furthermore, cholesterol led to an increase in encapsulation efficiency, and even improved the stability of phenolic compounds loaded in nanoliposomes during storage time. Fourier transform infrared (FTIR) spectroscopy confirmed the successful loading of the extract. Field emission scanning electron microscopy (FE-SEM) analysis revealed nano-sized spherical and almost-elliptical liposomes. For jelly powders, the water solubility index ranged from 39.5 to 43.7% ( > 0.05), and the hygroscopicity values ranged between 1.22 and 9.36 g/100 g ( < 0.05). In conclusion, nanoencapsulated extract displayed improved stability and can be used in jelly preparation without any challenge or unfavorable perception.
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http://dx.doi.org/10.3390/molecules29122804 | DOI Listing |
Langmuir
September 2025
Product & Process Engineering, Department of Chemical Engineering, Faculty of Applied Sciences, Delft University of Technology, 2629 HZ Delft, The Netherlands.
Noble metal nanoparticles (NPs), particularly platinum (Pt), are widely used in heterogeneous catalysis due to their exceptional activity. However, controlling their size and preventing sintering during synthesis remains a major challenge, especially when aiming for high dispersion and stability on supports such as graphene. Atomic layer deposition (ALD) has emerged as a promising method to address these issues, yet conventional processes often lead to broad particle size distributions (PSDs).
View Article and Find Full Text PDFPharm Dev Technol
September 2025
School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, wenhua Road 103, Shenyang 110016, PR China.
Nimodipine (NMP), a poorly water-soluble small-molecule agent, demonstrates notable therapeutic limitations in addressing cerebral vasospasm secondary to subarachnoid hemorrhage (SAH). Owing to its inherent physicochemical properties characterized by low oral bioavailability, rapid elimination half-life, and extensive first-pass metabolism, conventional formulations necessitate frequent dosing regimens to sustain therapeutic plasma concentrations. These pharmacological challenges collectively result in suboptimal patient adherence, marked plasma concentration fluctuations, and recurrent vascular irritation.
View Article and Find Full Text PDFJ Pharm Pharmacol
September 2025
Facultad de Farmacia y Bioquímica, Departamento de Tecnología Farmacéutica, Cátedra de Tecnología Farmacéutica II, Universidad de Buenos Aires, C1113AAD Buenos Aires, Argentina.
Objectives: To develop the orphan drug benznidazole (BNZ) in orally disintegrating tablets, for the neglected disease American Trypanosomiasis (Chagas disease) therapy. Although children are highly affected by this disease, there are no specific commercial pharmaceutical preparations for this age group in Argentina and in many other countries.
Methods: In the production process, co-milling in a ball mill was applied to enhance dissolution rates, followed by direct compression.
Langmuir
September 2025
College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, PR China.
Sodium-ion batteries are promising candidates for large-scale energy storage due to their low cost and resource abundance. However, their cathode materials suffer from poor conductivity and limited cycling stability. Here, we report a Prussian blue (PB)-based cathode hybridized with carboxyl-functionalized carbon nanotubes (CNTs) via a glutamic acid-assisted in situ coordination route.
View Article and Find Full Text PDFLangmuir
September 2025
College of Petroleum Engineering, Liaoning Petrochemical University, Fushun 113001, Liaoning, China.
In recent years, amino acids have garnered extensive attention as environmentally friendly, small-dose additives for modulating hydrate formation and aggregation behavior. Amino acids, due to their amphiphilic nature, can adsorb at the gas-liquid interface and on hydrate crystal surfaces, thereby modifying interfacial properties and influencing crystal growth patterns. In our measurements, the amino acids displayed a concentration-dependent "double effect".
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