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Direct laser acceleration (DLA) of electrons in plasmas of near-critical density (NCD) is a very advancing platform for high-energy PW-class lasers of moderate relativistic intensity supporting Inertial Confinement Fusion research. Experiments conducted at the PHELIX sub-PW Nd:glass laser demonstrated application-promising characteristics of DLA-based radiation and particle sources, such as ultra-high number, high directionality and high conversion efficiency. In this context, the bright synchrotron-like (betatron) radiation of DLA electrons, which arises from the interaction of a sub-ps PHELIX laser pulse with an intensity of 10 W/cm with pre-ionized low-density polymer foam, was studied. The experimental results show that the betatron radiation produced by DLA electrons in NCD plasma is well directed with a half-angle of 100-200 mrad, yielding (3.4 ± 0.4)·10 photons/keV/sr at 10 keV photon energy. The experimental photon fluence and the brilliance agree well with the particle-in-cell simulations. These results pave the way for innovative applications of the DLA regime using low-density pre-ionized foams in high energy density research.
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http://dx.doi.org/10.1038/s41598-024-65490-7 | DOI Listing |
ACS Omega
September 2025
Department of Chemistry, American University of Beirut, P.O. Box 11-0236, Riad El-Solh, 1107 2020 Beirut, Lebanon.
Fractal growth in reaction-diffusion frameworks (RDF) offers a powerful paradigm for understanding self-assembly in chemical and materials systems. However, its connection to diffusion-limited aggregation (DLA) remains underexplored. Here, we present the first quantitative demonstration of RDF-driven fractal crystallization of benzoic acid (BA), revealing a direct correlation among fractal dimension, diffusion rate, and gel-matrix chemistry.
View Article and Find Full Text PDFNat Commun
August 2025
Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
Conventional genome editing tools rely on DNA double-strand breaks (DSBs) and host recombination proteins to achieve large insertions, resulting in heterogeneous mixtures of undesirable outcomes. We recently leveraged a type I-F CRISPR-associated transposase, PseCAST, for DSB-free DNA integration in human cells, albeit at low efficiencies; multiple lines of evidence suggest DNA binding may be a bottleneck for higher efficiencies. Here we report structural determinants of DNA recognition by the PseCAST QCascade complex using single-particle cryogenic electron microscopy (cryoEM), revealing subtype-specific interactions and RNA-DNA heteroduplex features.
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August 2025
Medical Bionanotechnology Lab, Department of Obstetrics and Gynaecology, Centre for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Thandalam, Chennai, 602101 India.
Unlabelled: Masking drugs by entrapping them in the immune-evasive materials facilitates targeted delivery to specific parts of the body. Cancers, including lung cancer and ascitic tumors, remain significant threats to human life, with limited effective treatment options. In the present study, to specifically target lung cancer and Dalton's lymphoma ascitic (DLA) cells, we synthesized green silver nanoparticles (NS-AgNps) using (NS) seeds extract, with thymoquinone as the reducing and capping agent, confirmed by GC-MS analysis.
View Article and Find Full Text PDFPeptides
September 2025
Gastroenterology Diagnosis and Treatment Center, The First Hospital of Hebei Medical University, Donggang Road 89, Shijiazhuang, Hebei 050031, China; Department of General Surgery, Hebei Key Laboratory of Colorectal Cancer Precision Diagnosis and Treatment, The First Hospital of Hebei Medical Univer
Background: The neurokinin-B (NKB)/neurokinin-3-receptor (NK3R) pathway is involved in the inflammatory response. However, its role in the disruption of intestine mucosal barrier during mechanical intestinal obstruction (IO) remains unknown.
Methods: We collected serum samples from 30 mechanical IO patients and 30 healthy volunteers and measured the serum levels of NKB, lipopolysaccharide (LPS), diamine oxidase (DAO), and D‑lactate (D‑LA) by using ELISA.
Environ Sci Pollut Res Int
May 2025
Department of Life Sciences, Christ University, Bangalore, Karnataka, 560029, India.
While there are exciting possibilities in nanotechnology, creating environmentally safe nanoparticles with a variety of uses in photocatalysis and biomedicine continues to be a significant issue. This work addresses the gap by introducing Quassia indica leaf extract as a bio reductant and stabilizer in the green synthesis of cobalt oxide-zinc oxide nanoparticles (QI: CoO/ZnO NP). The synthesized nanoparticles were characterized using various techniques, including UV-visible spectroscopy, X-ray diffraction (XRD), dynamic light scattering (DLS), high resolution transmission electron microscopy (HR-TEM), selected area electron diffraction (SAED), Fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FE-SEM), and energy dispersive X-ray spectroscopy (EDX).
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