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http://dx.doi.org/10.1016/j.biopsych.2024.05.009 | DOI Listing |
Neurosurgery
August 2025
Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Background And Objectives: Extent of resection (EOR) is a recognized predictor of survival in adults with diffuse high-grade glioma (HGG) but can only be calculated postoperatively. We developed novel whole-brain tractography (WBT)-based metrics to quantify tumor resectability and predict survival outcomes using only preoperative data.
Methods: Consecutive adults with biopsied or resected HGGs were retrospectively reviewed.
AJNR Am J Neuroradiol
July 2025
From the Center for Advanced Imaging Innovation and Research (CAI2R) & Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology (S.C, P.S, S.S, T.M.S., Y.W.L), and Department of Neurosurgery (A.M), New York University Grossman School of Medicine, New York, NY, USA; Departmen
Background And Purpose: Accurate localization of the ventral intermediate nucleus (VIM) within the dentatorubrothalamic tract (DRTT) is critical for effective neurosurgical treatment of essential tremor (ET). This study evaluated the feasibility and anatomical specificity of quantitative susceptibility mapping (QSM) for direct VIM/DRTT visualization, comparing it with conventional diffusion tractography-based reconstructions.
Materials And Methods: Twenty-seven participants (10 healthy controls, 17 ET patients) were enrolled across two institutions and imaged on 3T MRI systems.
Stereotact Funct Neurosurg
June 2025
Department of Electrical and Electronics Engineering, National Magnetic Resonance Research Center (UMRAM), Bilkent University, Ankara, Turkey.
Introduction: In Parkinson's disease (PD) patients, modulation of the fibre tracts of the cortico-basal ganglia-thalamo-cortical loop is the presumed mechanism of action of deep brain stimulation (DBS) of the subthalamic nucleus (STN). Therefore, we explored patient-individual cortical structural connectivity of the volume of tissue activated (VTA), as well as DBS-induced modulation of fibre tracts connecting the STN with cortical and subcortical nodes, and their correlation with therapeutic effects.
Methods: A retrospective cohort of n = 69 PD patients treated with bilateral DBS of the STN was analysed.
Neuroimage
May 2025
Department of Biomedical Engineering, Duke University, Durham, NC, United States; Department of Neurosurgery, Duke University, Durham, NC, United States. Electronic address:
Introduction: Structural connectivity models of the brain are commonly employed to identify pathways that are directly activated during deep brain stimulation (DBS). However, various connectomes differ in the technical parameters, parcellation schemes, and methodological approaches used in their construction.
Objective: The goal of this study was to compare and quantify variability in DBS pathway activation predictions when using different structural connectomes, while using identical electrode placements and stimulation volumes in the brain.
Hum Brain Mapp
December 2024
School of Information and Communication Engineering, University of Electronic Science and Technology of China, Chengdu, China.