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Cross-sectional imaging plays a crucial role in the detection, diagnosis, staging, and resectability assessment of intra- and extrahepatic cholangiocarcinoma. Despite this vital function, there is a lack of standardized CT and MRI protocol recommendations for imaging cholangiocarcinoma, with substantial differences in image acquisition across institutions and vendor platforms. In this review, we present standardized strategies for the optimal imaging assessment of cholangiocarcinoma including contrast media considerations, patient preparation recommendations, optimal contrast timing, and representative CT and MRI protocols with individual sequence optimization recommendations. Our recommendations are supported by expert opinion from members of the Society of Abdominal Radiology's Disease-Focused Panel (DFP) on Cholangiocarcinoma, encompassing a broad array of institutions and practice patterns.
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http://dx.doi.org/10.1007/s00261-024-04216-9 | DOI Listing |
Clin J Gastroenterol
September 2025
Department of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka, 541-8567, Japan.
Hepatic reactive lymphoid hyperplasia (RLH), also known as hepatic pseudolymphoma, is a rare benign condition that predominantly affects middle-aged-to-elderly women and is often associated with autoimmune disorders. The imaging features of hepatic RLH frequently mimic those of malignant hepatic tumors, such as hepatocellular carcinoma (HCC), cholangiocarcinoma, or metastatic liver tumors, making its diagnosis based solely on imaging modalities challenging, often leading to unnecessary surgical resection. However, the optimal diagnostic strategy for hepatic RLH remains controversial.
View Article and Find Full Text PDFJ Med Internet Res
August 2025
Department of Radiology, The First Hospital of Jilin University, 71 Xinxin Street, Chaoyang District, Changchun City, Jilin Province, China, Jilin, CN.
Background: Despite AI models demonstrating high predictive accuracy for early cholangiocarcinoma(CCA) recurrence, their clinical application faces challenges such as reproducibility, generalizability, hidden biases, and uncertain performance across diverse datasets and populations, raising concerns about their practical applicability.
Objective: This meta-analysis aims to systematically assess the diagnostic performance of artificial intelligence (AI) models utilizing computed tomography (CT) imaging to predict early recurrence of CCA.
Methods: A systematic search was conducted in PubMed, Embase, and Web of Science for studies published up to May 2025.
Hepatobiliary Surg Nutr
August 2025
Department of Biomedical Sciences, Humanitas University, Milan, Italy.
Quant Imaging Med Surg
September 2025
Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Background: Magnetic resonance imaging (MRI) plays a crucial role in the diagnosis of abdominal conditions. A comprehensive assessment, especially of the liver, requires multi-planar T2-weighted sequences. To mitigate the effect of respiratory motion on image quality, the combination of acquisition and reconstruction with motion suppression (ARMS) and respiratory triggering (RT) is commonly employed.
View Article and Find Full Text PDFGut
August 2025
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele (MI), Italy
Background: Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive biliary tract cancer with a poor prognosis and a complex tumour microenvironment (TME) that remains poorly understood.
Objective: This study aimed to investigate the phenotypic and molecular characteristics of B lymphocytes, their interactions with the TME and their prognostic implications.
Design: B-cell compartments in the tumour, peritumour, and peripheral blood of iCCA patients were analysed using multimodal single-cell technologies.