Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1152/ajpgi.00135.2024 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Exploring the use of panaxynol from American ginseng to combat intestinal inflammation and colon cancer.
Am J Physiol Gastrointest Liver Physiol
August 2024
Department of Regenerative Medicine & Cell Biology, Medical University of South Carolina, Charleston, South Carolina, United States.
Chemical composition and biological activities of Royle: an unexplored medicinal plant of Indian himalayan region.
Nat Prod Res
August 2025
CEA and CC, G. B. Pant National Institute of Himalayan Environment, Almora, India.
In this study, different parts (leaf, bark, and fruit) of were investigated to explore its chemical composition and biological activities. The GC-MS analysis confirmed the presence of fifty-seven, eighty-one, and forty-six compounds in leaf, fruit, and bark extract, respectively. The important identified bioactive compounds include 1,3,4,5-tetrahydroxy-cyclohexanecarboxylic acid (quinic acid), falcarinol, tetradecanoic acid, and isopropyl myristate.
View Article and Find Full Text PDFPanaxynol improves crypt and mucosal architecture, suppresses colitis-enriched microbes, and alters the immune response to mitigate colitis.
Am J Physiol Gastrointest Liver Physiol
May 2024
Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, South Carolina, United States.
Ulcerative colitis (UC) is an idiopathic inflammatory disease of the large intestine, which impacts millions worldwide. Current interventions aimed at treating UC symptoms can have off-target effects, invoking the need for alternatives that may provide similar benefits with less unintended consequences. This study builds on our initial data, which showed that panaxynol-a novel, potent, bioavailable compound found in American ginseng-can suppress disease severity in murine colitis.
View Article and Find Full Text PDFEvaluation of free radical quenching, anti-inflammatory activity together with anticancer potential of and characterization of novel molecules from its extract through high resolution-liquid chromatography mass spectrometry coupled to structural biochemistry approach.
J Biomol Struct Dyn
November 2023
Department of Sericulture, Govt. Degree College for Women, Anantnag, Jammu & Kashmir, India.
, a perennial (herbaceous) belonging to Caryophyllaceae has been traditionally used for treating different complications. However, the free radical scavenging effect, anti-inflammatory activity and anticancer property of methanolic extract of this plant has not been addressed. Most importantly, the chemical constituents present in the extract of responsible for its diverse activities have not been scrutinized till date.
View Article and Find Full Text PDFPanaxynol induces fibroblast-like synovial cell apoptosis, inhibits proliferation and invasion through TLR4/NF-κB pathway to alleviate rheumatoid arthritis.
Int Immunopharmacol
December 2021
Department of Pharmacy, The First Affiliated Hospital of Soochow University, Suzhou 215006, China. Electronic address:
Background And Purpose: Panaxynol (PAL, PubChem CID: 5281149) is a common natural minor component in Umbelliferae plants, such as Radix Saposhnikoviae Divaricatae. Modern pharmacology studies show that PAL has nutritional value and anti-inflammatory and other pharmaceutical activities. Therefore, the scientific hypothesis of PAL in the treatment of rheumatoid arthritis was put forward, and the hypothesis was further verified by Fibroblast-like synovial cells (RA-FLS) and Collagen Induced Arthritis (CIA) rats models.
View Article and Find Full Text PDF