98%
921
2 minutes
20
This article reviews key concepts in the epidemiology, clinical features, diagnosis and management of ocular syphilis. It is not a systematic review or meta-analysis, but highlights the critical clinical features and investigations in patients with ocular syphilis. It reviews the overlap and interplay between ocular and neuro syphilis and provides practical guidance to diagnose and manage patients with ocular syphilis.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11306553 | PMC |
http://dx.doi.org/10.1038/s41433-024-03150-w | DOI Listing |
Cureus
August 2025
Ophthalmology, Henry Ford Health System, Detroit, USA.
This report discusses a case of diagnosing neurosyphilis in a non-classical presentation with confounding test results needing a deliberate and multidisciplinary diagnostic approach. A 38-year-old immunocompetent male presented with uveitis and a skin rash. Although serology was positive for syphilis (rapid plasma reagin 1:128), it was also positive for tuberculosis, and a dermatology consult identified the rash as psoriasis, creating a complex diagnostic picture.
View Article and Find Full Text PDFBrain
September 2025
Department of Neurology, University of Washington, Seattle, WA, USA.
The incidence of syphilis has increased world-wide over the last ∼25 years, and this increase has been accompanied by a resurgence of neurosyphilis. This review sets the stage for understanding neurosyphilis by briefly summarizing the clinical and laboratory findings in uncomplicated syphilis. It then addresses the epidemiology, clinical manifestations, and treatment of neurosyphilis beginning with information from the pre-penicillin era and extending to modern studies.
View Article and Find Full Text PDFCureus
July 2025
Ophthalmology, University Hospital Southampton National Health Service (NHS) Foundation Trust, Southampton, GBR.
Aim: This case series seeks to share our experience with ocular syphilis by reporting the clinical findings and management of nine diagnosed cases.
Materials And Methods: This retrospective case series comprises nine patients who presented to the Ophthalmology Department of Southampton General Hospital between 2013 and 2022. The series provides a comprehensive report on patients diagnosed with ocular syphilis, detailing the severity of the condition, associated symptoms, and the treatments administered.
Eur J Ophthalmol
August 2025
Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
PurposeTo report a rare case of acute corneal hydrops and conjunctival ulceration secondary to acquired syphilis.MethodsA male in his late 30's presented with redness, pain, and watering in both eyes and sudden loss of vision in the left eye. Examination revealed bilateral conjunctival ulcers along with well-circumscribed corneal edema with blunt stunted intrinsic vessel in the left eye.
View Article and Find Full Text PDFClin Infect Dis
August 2025
Division of Infectious Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.