Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Cell culture is a fundamental tool for cell-based assays in biological and preclinical research. The measurements of cell culture, including cell count, viability, and metabolic activity, can reflect the conditions of cells under culture conditions. The conventional cell culture and detection methods have problems such as high consumption of reagents and samples, inability to monitor cell status in real time, and difficulty in spatiotemporally adjusting the cell microenvironment. A cell impedance sensor measures changes in the electrical impedance of cells through alternating current, enabling real-time monitoring of impedance changes caused by cell activities such as attachment, growth, proliferation, and migration. Microfluidic chips are praised for reducing complex biological processes, integrating multiple analysis modes, and achieving high automation in detection. Integrating microfluidic chips with cell impedance sensors greatly improves the capability and efficiency of cell-related analysis. This review outlines the application of microfluidic chip-based impedance sensors in 2D and 3D cell systems and summarizes the research progress in application of such sensors in research on cell growth, proliferation, viability, metabolic activity, and drug screening. Finally, this review prospects the future development trends and possible challenges, providing ideas for the development of microfluidic chips integrated with electrical impedance sensors in drug screening.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.13345/j.cjb.230668 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Deep Learning-Assisted Organogel Pressure Sensor for Alphabet Recognition and Bio-Mechanical Motion Monitoring.
Nanomicro Lett
September 2025
Nanomaterials & System Lab, Major of Mechatronics Engineering, Faculty of Applied Energy System, Jeju National University, Jeju, 63243, Republic of Korea.
Wearable sensors integrated with deep learning techniques have the potential to revolutionize seamless human-machine interfaces for real-time health monitoring, clinical diagnosis, and robotic applications. Nevertheless, it remains a critical challenge to simultaneously achieve desirable mechanical and electrical performance along with biocompatibility, adhesion, self-healing, and environmental robustness with excellent sensing metrics. Herein, we report a multifunctional, anti-freezing, self-adhesive, and self-healable organogel pressure sensor composed of cobalt nanoparticle encapsulated nitrogen-doped carbon nanotubes (CoN CNT) embedded in a polyvinyl alcohol-gelatin (PVA/GLE) matrix.
View Article and Find Full Text PDFNanocomposite enhanced molecularly imprinted polymer for electrochemical detection of naringenin in plant-based samples.
Mikrochim Acta
September 2025
Faculty of Pharmacy, Department of Analytical Chemistry, Ankara University, Ankara, Türkiye.
A novel molecularly imprinted polymer (MIP)-based electrochemical sensor has been developed for the selective detection of naringenin (NAR) in various real-world samples, including plant extracts, wine, and herbal supplements. To enhance the active surface area and porosity of the glassy carbon electrode (GCE), a 2D/0D nanocomposite composed of graphene oxide (GO) and cobalt ferrite (CFO) nanoparticles, CFO_GO, was incorporated into the sensor design. 4-aminobenzoic acid (4-ABA) was selected as the functional monomer to prepare the MIPs.
View Article and Find Full Text PDFPolypyrrole functionalized (TiCT -SnO NPs) nanocomposite-based hybrid capacitive electrode for electrochemical detection of .
RSC Adv
September 2025
Department of Chemical Engineering, Jashore University of Science and Technology Jashore 7408 Bangladesh
Bacterial detection is crucial for accurate clinical diagnostics and effective environmental monitoring. Particularly, , a pathogenic bacterium, can cause a wide range of infections, including meningitis, bloodstream infections, pneumonia, urinary tract infections, and wound or surgical site infections. Herein, a polypyrrole (PPy) functionalized TiCT -tin dioxide nanoparticle (SnO NPs) nanocomposite-based hybrid capacitive electrode for the electrochemical detection of ATCC 700603 is developed.
View Article and Find Full Text PDFLabel-free electrochemical biosensor for real-time detection of live Salmonella typhimurium in salad samples using non-Faradaic EIS.
Biosens Bioelectron
September 2025
Department of Bioengineering, University of Texas at Dallas, Richardson, TX, 75080, USA; EnLiSense LLC, Allen, TX, 75013, USA. Electronic address:
Rapid detection of live Salmonella typhimurium in food is critical for preventing contamination and protecting public health. Traditional methods, though reliable, are slow, costly, and require centralized labs. Many existing biosensors primarily detect dead bacteria, increasing false-positive risks.
View Article and Find Full Text PDFCharge Transport, Dielectric Response, and Magnetoconductance in Organic Diodes Based on a Novel P18‑8 Conjugated Polymer for Magnetic Sensor Applications.
ACS Omega
August 2025
Laboratoire Matériaux Avancés et Phénomènes Quantiques, Faculté des Sciences de Tunis, Université de Tunis El Manar, Campus Universitaire, Tunis 2092, Tunisia.
This paper reports the use of P18-8, a novel conjugated polymer combining poly-(1,4-phenylene-ethynylene) and poly-(1,4-phenylene-vinylene), in the fabrication of an organic diode with the structure ITO/PEDOT:PSS/P18-8/LiF/Al. The electrical properties of the fabricated device were characterized using impedance spectroscopy across a frequency range of 100 Hz to 1 MHz at various applied voltages. The current density-voltage (-) characteristic exhibited ohmic behavior at low applied voltages, while at higher voltages, it conformed to the space charge limited current (SCLC) theory.
View Article and Find Full Text PDF