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http://dx.doi.org/10.1016/j.nefroe.2023.10.008 | DOI Listing |
J Dev Orig Health Dis
September 2025
Graduate Program in Health Science, Western São Paulo University (UNOESTE), Presidente Prudente, SP, Brazil.
The developmental origins of health and disease hypothesis suggests that environmental exposures during critical developmental windows increase the risk of disease later in life. Among these, endocrine disruptors (EDs) are particularly concerning due to their ubiquitous presence. The kidneys are highly susceptible to EDs toxicity during the perinatal period; however, long-term effects of ED mixtures on renal structure in aging remain unclear.
View Article and Find Full Text PDFEnviron Pollut
August 2025
FI-TRACE Group, Department of Chemistry, Faculty of Science, University of the Balearic Islands, Carretera de Valldemossa Km 7.5, E-07122, Palma de Mallorca, Illes Balears, Spain; Molecular Biology, Health Geography, and One Health Research group (MolONE) Research grup, Department of Fundamental Bio
There is a paucity of in vivo assays to investigate the potential deleterious effects of plastic-laden compounds in the gastrointestinal tract of mammals, compared to in vitro testing and ecotoxicity assays in marine organisms. This work aims to fill this gap through a comprehensive evaluation of the acute toxicokinetics and bioavailability of bisphenol A (BPA)-adsorbed medium-density polyethylene (PE) microplastics (MPs) (ca. 3000 μg BPA/g), with a mean particle size of 136 μm, which were administered via oral gavage at a mere 0.
View Article and Find Full Text PDFPathol Oncol Res
July 2025
Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
This case study delves into the link, between exposure to Bisphenol A (BPA) and kidney issues filling a gap in human focused research found in studies. The individual, a 72-year man with a history of BPA exposure in a plastics manufacturing facility experienced a gradual decline in kidney function over 18 months. Medical tests showed kidney disease with a buildup of lipofuscin in renal tubular cells upon examination.
View Article and Find Full Text PDFEnviron Res
June 2025
Pathology Post Graduate Program, Fluminense Federal University (UFF), Niterói, RJ, Brazil; Cardiovascular Sciences Graduate Program, Fluminense Federal University (UFF), Niterói, RJ, Brazil; Nutrition Sciences Graduate Program, Fluminense Federal University (UFF), Niterói, RJ, Brazil. Electronic
Objective: To investigate the impact of bisphenol S (BPS) exposure on kidney function parameters, renal histopathology, and inflammatory markers in mice that received a high-fat diet.
Methods: 43 male C57BL/6 mice were divided into control (C; n = 9), high-fat diet (HF; n = 10), control + BPS (CBPS; n = 12), and high-fat diet + BPS (HFBPS; n = 12) groups. The drinking water offered BPS (25 μg/kg body mass/day).
J Biochem Mol Toxicol
July 2025
State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
Bisphenol A (BPA), an endocrine-disrupting chemical ubiquitously present in environmental matrices, has emerged as a critical public health concern due to its potential multiorgan toxicity. Although epidemiological and experimental evidence associates BPA exposure with diverse pathologies including metabolic syndrome, carcinogenesis, and hepatorenal dysfunction, the molecular pathogenesis underlying BPA-induced nephrotoxicity remains poorly characterized. To systematically elucidate these mechanisms, we employed an integrative network toxicology approach interrogating multiple pharmacological databases (ChEMBL, STITCH) and disease repositories (GeneCards, OMIM) to identify putative molecular targets.
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