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Purpose: The increase in thyroid cancer incidence has inevitably led to an increase in thyroid cancer surgeries. This meta-regression analysis aimed to determine if the rate of post-thyroidectomy complications changes by year.
Materials And Methods: PubMed and Embase databases were used to perform a systematic literature search of studies published from January 1, 2005, using the keywords "thyroidectomy" and "complication." A meta-regression was performed for post-thyroidectomy hypocalcemia and bleeding.
Results: This meta-analysis included 25 studies involving 927751 individuals. Through the years of publications in this study, there was no significant difference in the proportion of post-thyroidectomy hypocalcemia and bleeding (=0.9978, 0.6393).
Conclusion: Although the number of thyroid surgeries has recently increased, the incidence of post-thyroidectomy hypocalcemia and bleeding did not significantly increase.
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http://dx.doi.org/10.3349/ymj.2023.0266 | DOI Listing |
JAMA Pediatr
September 2025
Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.
Importance: Neonatal intensive care has advanced over recent decades, yet premature birth remains associated with increased neonatal mortality and morbidity.
Objective: To describe health service use, morbidity, and medication needs up to age 5 years in a contemporary cohort of children born preterm.
Design, Setting, And Participants: This population-based cohort study was conducted in British Columbia (BC), Canada, using health service and pharmacy data linked using provincial administrative databases.
Front Endocrinol (Lausanne)
September 2025
Department of Ultrasound, Shengjing Hospital, China Medical University, Shenyang, Liaoning, China.
This research aimed to investigate the preoperative risk factors for lymph node metastasis (LNM) in medullary thyroid carcinoma (MTC) using clinical, pathological, serological, ultrasound, and radiomics characteristics. Additionally, it aimed to explore the diagnostic precision of ultrasound (US) for MTC and LNM. A retrospective analysis of 111 nodules was eligible from 104 patients from January 1, 2000, to December 28, 2024.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
September 2025
Integrative Biology, University of Guelph, Guelph, ON, Canada.
Thyroid hormones (THs) are essential regulators of metabolism, homeostasis, and development in metazoans. The canonical genomic pathway involves THs binding to nuclear thyroid hormone receptors (NTHRs), which modulate gene expression in vertebrates. In contrast, non-genomic pathways involve THs interacting with membrane-bound or cytoplasmic receptors.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
September 2025
Department of Nuclear Medicine, Jiangxi Cancer Hospital, Nanchang, Jiangxi, China.
Background And Objective: Radioiodine-refractory differentiated thyroid cancer (RAIR-DTC) remains challenging to treat due to a lack of effective therapies. This study aimed to evaluate the efficacy and safety of combining anlotinib with iodine-125 (I) seed implantation in patients with RAIR-DTC.
Methods And Materials: We retrospectively compared three treatment groups in 52 patients with advanced RAIR-DTC: anlotinib monotherapy (Group A, = 14), I seed brachytherapy monotherapy (Group B, = 25), and combined therapy (Group C, = 13).
Front Biosci (Landmark Ed)
August 2025
General Surgery, Shanghai Pudong New District Traditional Chinese Medicine Hospital, 200120 Shanghai, China.
Background: The most common endocrine cancer, thyroid carcinoma (TC), has a dismal prognosis when it reaches an advanced stage. Integrin α-2 () has been implicated in cancer progression, influencing both DNA damage and repair mechanisms. However, it is unknown how ITGA2 influences these processes in TC.
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