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Article Abstract
The intermolecular [4 + 2] cycloaddition of -hydroxy benzyl alcohols with isochroman ketals was realized by CFCOH catalysis. A broad range of bisbenzannulated [6,6]-spiroketals were formed under the metal-free mild conditions in moderate to excellent yields (45-98%) with mostly excellent diastereoselectivities (up to >20 : 1 dr). Furthermore, the enantioselective version was also preliminarily investigated and the bisbenzannulated [6,6]-spiroketal was obtained with 61% ee in the presence of Sc(OTf)/Feng's chiral ,'-dioxide ligand. Some of the bisbenzannulated [6,6]-spiroketal products showed good antifungal activities against and .
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