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Article Abstract
Activated CD8 T cells directly kill target cells. Therefore, the regulation of their function is central to avoiding immunopathology. Mechanisms that curb effector functions in CD4 and CD8 T cells are mostly shared, yet important differences occur. Here, we focus on the control of CD8 T cell activity and discuss the importance of a poorly understood aspect of tolerance that directly impairs engagement of target cells: the downregulation of CD8. We contextualize this process and propose that it represents a key element during CD8 T cell modulation.
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| http://dx.doi.org/10.1016/j.it.2024.04.012 | DOI Listing |
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