98%
921
2 minutes
20
Traditional heat health warning systems focus on severe and extreme heat events at the district or regional level, often overlooking localized risk and protective factors such as healthcare access and urban green spaces. This approach considers less the varying impacts of heat within cities, including the phenomenon of Urban Heat Islands (UHIs) and the diverse needs of different populations. To address these shortcomings, a need for the development of an Urban Heat Health Warning and Information System (UHHWIS) that operates within the framework of Heat Health Action Plans is needed. Such a system integrates national acute heat health warnings with city-specific assessments of UHI effects and other relevant factors. The technical implementation of the UHHWIS involves the calculation and preprocessing of basic factors such as the Normalised Difference Vegetation Index (NDVI), imperviousness, and UHI intensity. Additionally, further factors are assessed, spatially processed, and provided in accordance with Open Geospatial Consortium (OGC) standards. An iso-area analysis is conducted to evaluate the accessibility of protective factors, such as urban green spaces, drinking wells, hospitals, physicians, and pharmacies, based on the city's road topology. One crucial factor considered in the system is the casting of shadows, which is influenced by both time and location and facilitated through deck.gl. The developed template encompasses all these components into a unified system aimed at protecting vulnerable and risk groups, such as the elderly, through resilient, climate-adapted urban planning. The system provides warnings and information tailored to the urban morphology and prevailing conditions, complemented by a catalogue of potential short- to long-term measures focused on behavioral changes and climate-resilient urban planning strategies. The template can be adapted for use in various European cities, offering valuable insights to decision-makers in city administration for mitigating thermal stress and enhancing resilience against urban heat nowadays and in future.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.envint.2024.108718 | DOI Listing |
J Virol
September 2025
National Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, China.
Japanese encephalitis virus (JEV) is a significant flavivirus that poses a threat to public health, as it induces encephalitis in humans and reproductive disorders in sows. We have recently identified that zinc finger protein 33B (ZNF33B) is required for JEV infection by CRISPR-based functional genomic screening, yet the precise functions and mechanisms are not fully comprehended. In this study, ZNF33B was found to be involved in JEV infection, wherein it bound with JEV RNA to enhance its stability during replication.
View Article and Find Full Text PDFJ Biochem Mol Toxicol
September 2025
Department of Rehabilitation Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Heat shock protein family A member 4-like (HSPA4L) has been shown to be overexpressed in osteoarthritis (OA) patients, but its role in OA process still unknown. Chondrocytes were stimulated with interleukin-1β (IL-1β) to mimic OA cell model in vitro, and rat was injected with monosodium iodoacetate (MIA) to construct OA rat model in vivo. The expression of HSPA4L, methyltransferase-like 3 (METTL3) and extracellular matrix (ECM)-related markers was examined by qRT-PCR or western blot.
View Article and Find Full Text PDFJ Integr Neurosci
August 2025
Neurology Department, Neurology Neurophysiology Center, 1180 Vienna, Austria.
Stem Cells Int
August 2025
R&D Center, Wuhan Hamilton Biotechnology Co. Ltd, Wuhan, Hubei, China.
Osteoarthritis (OA) is the leading joint disease that causes joint pain and disability. Despite increasing progress regarding the therapeutic potential of human umbilical cord mesenchymal stem cells (UC-MSCs) for OA, effective strategies for the treatment of OA using UC-MSCs have not yet been developed in clinical practice. Our present study has proven that the early stage in OA rats is the main development stage of nod-like receptor heat protein domain protein 3 (NLRP3)-mediated synovial inflammation.
View Article and Find Full Text PDFACS Omega
September 2025
Department of Health Sciences, College of Natural Sciences, Can Tho University, Can Tho 94000, Vietnam.
Anthocyanins, natural antioxidants found in L. flowers, exhibit instability when exposed to high temperatures. Therefore, to heat-protect the anthocyanins, this investigation produced extract-loaded polymeric (polyethylenimine (PEI) or poly-(vinyl alcohol) (PVA)) functionalized silk fibroin nanoparticles using a green/sustainable process.
View Article and Find Full Text PDF