98%
921
2 minutes
20
Background: Traffic-related crashes are a leading cause of premature death and disability. The safe systems approach is an evidence-informed set of innovations to reduce traffic-related injuries and deaths. First developed in Sweden, global health actors are adapting the model to improve road safety in low- and middle-income countries via technical assistance (TA) programs; however, there is little evidence on road safety TA across contexts. This study investigated how, why, and under what conditions technical assistance influenced evidence-informed road safety in Accra (Ghana), Bogotá (Colombia), and Mumbai (India), using a case study of the Bloomberg Philanthropies Initiative for Global Road Safety (BIGRS).
Methods: We conducted a realist evaluation with a multiple case study design to construct a program theory. Key informant interviews were conducted with 68 government officials, program staff, and other stakeholders. Documents were utilized to trace the evolution of the program. We used a retroductive analysis approach, drawing on the diffusion of innovation theory and guided by the context-mechanism-outcome approach to realist evaluation.
Results: TA can improve road safety capabilities and increase the uptake of evidence-informed interventions. Hands-on capacity building tailored to specific implementation needs improved implementers' understanding of new approaches. BIGRS generated novel, city-specific analytics that shifted the focus toward vulnerable road users. BIGRS and city officials launched pilots that brought evidence-informed approaches. This built confidence by demonstrating successful implementation and allowing government officials to gauge public perception. But pilots had to scale within existing city and national contexts. City champions, governance structures, existing political prioritization, and socio-cultural norms influenced scale-up.
Conclusion: The program theory emphasizes the interaction of trust, credibility, champions and their authority, governance structures, political prioritization, and the implement-ability of international evidence in creating the conditions for road safety change. BIGRS continues to be a vehicle for improving road safety at scale and developing coalitions that assist governments in fulfilling their role as stewards of population well-being. Our findings improve understanding of the complex role of TA in translating evidence-informed interventions to country-level implementation and emphasize the importance of context-sensitive TA to increase impact.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11084027 | PMC |
http://dx.doi.org/10.1186/s12992-024-01041-z | DOI Listing |
Chem Res Toxicol
September 2025
C.F.E.B Sisley Paris, 32 Avenue des Béthunes, 95310 Saint Ouen L'Aumône, France.
The development of alternative methods to animal testing has gained momentum over the years, including the rapid growth of methods, which are faster and more cost-effective. A large number of tools have been published, focusing on Read-Across, (quantitative) Structure-Activity Relationship ((Q)SAR) models, and Physiologically Based Pharmacokinetic (PBPK) models. All of these methods play a crucial role in the risk assessment for cosmetics.
View Article and Find Full Text PDFJMIR Dermatol
September 2025
College of Osteopathic Medicine, Rocky Vista University, 8401 S Chambers Road, Parker, CO, 80112, United States, 1 9253236431.
Dermal fillers have gained increasing popularity for their ability to enhance facial symmetry, restore volume, and improve skin texture. However, their use in patients with cancer undergoing active chemotherapy and radiation therapy poses unique challenges, as these treatments can alter both the safety profile and efficacy of filler procedures. Chemotherapy can interfere with normal wound healing and immune responses, warranting a more cautious and individualized approach when considering dermal fillers in this population.
View Article and Find Full Text PDFBioinspir Biomim
September 2025
Mechanical Intelligence (MI) Research Group, London South Bank University, 103 Borough Road, London, London, SE1 0AA, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.
Conventional rigid grippers remain the most-used robotic grippers in industrial assembly tasks. However, they are limited in their ability to handle a diverse range of objects. This study draws inspiration from nature to address these limitations, employing multidisciplinary methods, such as computer-aided design, parametric modeling, finite element analysis, 3D printing, and mechanical testing.
View Article and Find Full Text PDFAccid Anal Prev
September 2025
Department of Traffic Engineering and Key Laboratory of Road and Traffic Engineering Ministry of Education, Tongji University, Shanghai 201804, China. Electronic address:
In future traffic environments dominated by highly autonomous vehicles (AVs), pedestrians may face challenges in accurately interpreting AV behavior, thereby potentially increasing the risk of pedestrian-AV interactions. External human-machine interfaces (eHMIs) have been proposed to facilitate communication between AVs and pedestrians; however, comprehensive evaluations using objective data from real-world interactions are limited. This study developed a systematic evaluation framework grounded in the ISO 9241-11 standard, integrating four key indicators: decision accuracy, comprehensibility, decision efficiency, and perceived safety.
View Article and Find Full Text PDFInt J Nurs Stud
August 2025
Florence Nightingale Faculty of Nursing Midwifery and Palliative Care, Cicely Saunders Institute of Palliative Care, Policy and Rehabilitation, King's College London, Bessemer Road, London SE5 9PJ, UK; Sussex Community NHS Foundation Trust, Brighton General Hospital, Elm Grove, Brighton, East Sussex
Background: People with advanced illness at home, and their families, rely on 'out-of-hours' services provided by community, primary and specialist palliative care services. Home is commonly expressed as the preferred place to be cared for and die, and an increasing proportion of people are dying at home, but what constitutes 'good' care is poorly understood from the combined perspectives of healthcare professionals and patients and family caregivers.
Objective: To understand the convergence and divergence of the perspectives of healthcare professionals with those of patients and family caregivers, on priorities for home-based palliative care in the 'out-of-hours' period in the UK.