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Concomitant use of anti-leishmanial therapy and antibacterial prophylaxis reduces plasma LPS levels and improves several aspects of experimental Leishmania infantum infection in golden hamsters.
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Methods: Golden hamsters were grouped in: G1-uninfected; G2-infected with L.
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Vitamin B12 is a vital water-soluble vitamin containing a central cobalt atom within its corrin ring structure. It exists in several derivatives, among which methylcobalamin (MeCbl) and adenosylcobalamin (AdCbl) are the biologically active forms that serve as cofactors in essential enzymatic reactions. Although the neurological and hematological consequences of vitamin B12 deficiency have been extensively studied, its role in immune regulation remains less well understood.
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Exosome-mediated co-delivery of superoxide dismutase and chondroitinase ABC for multiple sclerosis therapy.
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Multiple sclerosis is an autoimmune demyelinating disease, and its effective treatment is a great challenge. As a typical animal model for studying multiple sclerosis, experimental autoimmune encephalomyelitis (EAE) is characterized by inflammation, demyelination, gliosis and axonal loss. Thus, simultaneous regulation of neuroinflammation and remyelination may be a useful strategy against EAE.
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