Retrospective Cohort Study of Early versus Delayed Ballon Kyphoplasty Intervention for Osteoporotic Vertebral Fracture Treatment.

: To investigate the outcomes of early balloon kyphoplasty (BKP) intervention compared with late intervention for osteoporotic vertebral fracture (OVF). : Osteoporotic vertebral fracture can lead to kyphotic deformity, severe back pain, depression, and disturbances in activities of daily living (ADL). Balloon kyphoplasty has been widely utilized to treat symptomatic OVFs and has proven to be a very effective surgical option for this condition. Furthermore, BKP is relatively a safe and effective method due to its reduced acrylic cement leakage and greater kyphosis correction. : A retrospective cohort study was conducted at our hospital for patients who underwent BKP for osteoporotic vertebral fractures in the time frame between January 2020 and December 2022. Ninety-nine patients were included in this study, and they were classified into two groups: in total, 36 patients underwent early BKP intervention (EI) at <4 weeks, and 63 patients underwent late BKP intervention (LI) at ≥4 weeks. We performed a clinical, radiological and statistical comparative evaluation for the both groups with a mean follow-up of one year. : Adjacent segmental fractures were more frequently observed in the LI group compared to the EI group (33.3% vs. 13.9%, = 0.034). There was a significant improvement in postoperative vertebral angles in both groups ( = 0.036). The cement volume injected was 7.42 mL in the EI, compared with 6.3 mL in the LI ( = 0.007). The mean surgery time was shorter in the EI, at 30.2 min, compared with 37.1 min for the LI, presenting a significant difference ( = 0.0004). There was no statistical difference in the pain visual analog scale (VAS) between the two groups ( = 0.711), and there was no statistical difference in cement leakage ( = 0.192). : Early BKP for OVF treatment may achieve better outcomes and fewer adjacent segmental fractures than delayed intervention.