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Background: We assess the impact of bone health clinical management in breast cancer (BC) patients receiving adjuvant endocrine therapy and design a personalized clinical pathway to reduce bone loss in an Italian research hospital.
Methods: The primary endpoint was to assess (through the process improvement organizational method) the clinical pathway that post-surgical BC patients prescribed with endocrine therapy undergo to prevent bone loss. The secondary endpoint was to design a personalized clinical pathway for a prompt implementation of guidelines, to assess and possibly prescribe antiresorptive therapy.
Results: During the first year of the execution of the new Diagnostic Therapeutic Assistance Pathway, a 60% increase in Dual-Energy X-ray Absorptiometry evaluations within 30 days and a 39.5% increase in antiresorptive therapy prescription within 90 days (since the prescription of endocrine therapy) were shown, thus increasing patients' compliance.
Conclusion: Case managers and bone health specialists in this context can improve patients' adherence to therapies and bone health, helping physicians to expand their collaboration.
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http://dx.doi.org/10.3390/jpm14040371 | DOI Listing |
Trends Mol Med
September 2025
Institute of Pharmacology and Toxicology, University of Würzburg, 97078 Würzburg, Germany; Leibniz-Institut für Analytische Wissenschaften (ISAS) e.V., 44139 Dortmund, Germany. Electronic address:
Dysregulation of the RAF-MEK-ERK1/2 pathway is involved in the pathoetiology of many diseases. Its central role in cancer has led to the development of drugs targeting upstream receptors, RAS, and kinases in the extracellular signal-regulated kinase 1 (ERK1) and 2 (ERK2) signaling cascade. The use of these drugs in cancer therapy - together with ongoing monitoring of their effectiveness, evolving side-effects, and resistance mechanisms - has expanded our knowledge of both the physiological and pathological functions of ERK1/2 and could thus provide potential alternative therapeutic strategies.
View Article and Find Full Text PDFRev Infirm
September 2025
CHRU de Nancy, Service de neurologie, Unité de prise en charge des interactions neuropsychiatriques ACT N'PSY, 29 avenue du Maréchal-de-Lattre-de-Tassigny, CO 60034, 54035 Nancy, France. Electronic address:
At the crossroads of neurology and psychiatry, functional neurological disorders (FND) require detailed, coordinated management. Through the experience of the ACT N'PSY unit, this article shows how nurses, and in particular advanced practice nurses (APNs), are becoming key players: from psycho-education to clinical follow-up, coordination and networking, they are boosting the efficiency of care paths.
View Article and Find Full Text PDFExp Cell Res
September 2025
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Gastrointestinal Cancer Center, Peking University Cancer Hospital and Institute, Beijing, China. Electronic address:
Background: Enteric glial cells (EGCs) have been implicated in colorectal cancer (CRC) progression. This study aimed to develop and validate a prognostic model integrating EGC- and CRC-associated gene expression to predict patient survival, recurrence, metastasis, and therapy response.
Methods: Bulk and single-cell RNA sequencing data were analyzed, and a machine learning-based model was constructed using the RSF random forest algorithm.
Fish Shellfish Immunol
September 2025
Laboratory of Applied Immunology in Aquaculture, Department of Cell Biology, Embryology and Genetics, Federal University of Santa Catarina, 88035-972 Florianópolis, SC, Brazil. Electronic address:
Environmental and nutritional factors are critical in modulating the immune system of Penaeus vannamei, particularly under viral threats such as white spot syndrome virus (WSSV). This study evaluated the effects of two Amazonian plant-based feed additives, buriti (Mauritia flexuosa) and pracaxi (Pentaclethra macroloba) brans, on shrimp immunocompetence, oxidative balance, and resistance to WSSV. Shrimp were fed diets supplemented with 4% or 8% of each ingredient.
View Article and Find Full Text PDFMod Pathol
September 2025
Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address:
Uterine leiomyosarcoma (uLMS) is a rare and deadly gynecologic malignancy. uLMS is histologically heterogeneous and presents with a wide spectrum of tumor differentiation, with a broad range of genomic DNA instability, which can make the diagnosis and prognosis of uLMS challenging. Methylation has emerged as a useful molecular tool in tumor classification and diagnosis in certain neoplasms.
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