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Article Abstract
We explored the clinical-stage association of gastric intestinal metaplasia (IM) compared to cases of chronic non-atrophic gastritis (CNAG) and its relationship with virulence genotypes of () clinical isolates from patients with dyspepsia in Peru. This study was cross-sectional and included 158 clinical isolates; each isolate corresponded to a different Peruvian patient, genotyped by polymerase chain reaction to detect gene and EPIYA motifs, the gene (alleles , , , , , , , and subtypes , and ), the gene (alleles and ), and the gene (allele ). We observed that 38.6% presented with IM and that all clinical isolates were positive. The EPIYA-ABC motif was predominant (68.4%), and we observed a high frequency for the gene alleles (94.9%), (81.7%), (63.9%), and (70.9%). Strains with both alleles were also detected (69.6%) and 52.2% were positive. In addition, it was observed that the (PR: 2.42, 1.14 to 5.13, < 0.05) and (PR: 1.67, 1.13 to 2.45, < 0.01) genotypes were associated with IM. Our findings revealed the and risk genotypes predominance, and we provided clinically relevant associations between Peruvian patients with infection and IM clinical stage.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11047899 | PMC |
| http://dx.doi.org/10.3390/cancers16081476 | DOI Listing |
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