Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
High-risk pregnancies elevate maternal stress, impacting offspring neurodevelopment and behavior. This study, involving 112 participants, aimed to compare perceived stress, neurodevelopment, and behavior in high-risk and low-risk pregnancies. Two groups, high-risk and low-risk, were assessed during pregnancy for stress using hair cortisol and psychological analysis. At 24 months post-birth, their children's neurodevelopment and behavior were evaluated. Results revealed higher perceived stress and pregnancy-related concerns in high-risk pregnancies, contrasting with low-risk pregnancies. Offspring from high-risk pregnancies displayed elevated internalizing behavior scores, while low-risk pregnancies showed higher externalizing behavior scores. Additionally, women in low-risk pregnancies exhibited increased cortisol concentrations 24 months post-delivery. These findings underscore the necessity for early stress detection and prevention programs during pregnancy, particularly in high-risk cases, to enhance maternal and infant health.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1017/S0954579424000786 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
MicroRNA-mediated regulation of proliferation, lineage differentiation, and apoptosis in neural stem cells.
RNA Biol
September 2025
Department of Stem Cell Biology, School of Medicine, Konkuk University, Seoul, Republic of Korea.
Neural stem cells (NSCs) are multipotent stem cells with self-renewal capacity, able to differentiate into all neural lineages of the central nervous system, including neurons, oligodendrocytes, and astrocytes; thus, their proliferation and differentiation are essential for embryonic neurodevelopment and adult brain homoeostasis. Dysregulation in these processes is implicated in neurological disorders, highlighting the need to elucidate how NSCs proliferate and differentiate to clarify the mechanisms of neurogenesis and uncover potential therapeutic targets. MicroRNAs (miRNAs) are small, post-transcriptional regulators of gene expression involved in many aspects of nervous system development and function.
View Article and Find Full Text PDFEffects of Dexmedetomidine-Remifentanil on Neurodevelopment of Children after Inhalation Anesthesia: A Randomized Clinical Trial.
Anesthesiology
October 2025
Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
Background: Anesthetic exposure in young children raises concerns about neurodevelopmental safety, with preclinical evidence suggesting potential neurotoxicity of volatile anesthetics. This study aimed to assess whether the combination of dexmedetomidine and remifentanil, by reducing sevoflurane exposure, has any differential effect on neurodevelopmental outcomes in young children compared with sevoflurane alone.
Methods: This study was a prospective, double-blind, randomized clinical trial including children younger than 2 yr undergoing nonstaged, nonrepetitive surgeries.
Early Diagnosis and Intervention for Autism Spectrum Disorder.
Cureus
August 2025
Faculty of Medicine, Universidad de Costa Rica, San José, CRI.
Autism spectrum disorder (ASD) is a neurodevelopmental syndrome that impacts two main areas: social communication and restrictive or repetitive behaviors. Other symptoms and comorbidities may be manifested, according to the different clinical presentations and severity levels. ASD diagnosis can be performed by two years of age; however, certain diagnostic challenges may lead to a late diagnosis and significant intervention delay.
View Article and Find Full Text PDFNeurodevelopmental considerations for transcranial magnetic stimulation trials in youth.
Neuropsychopharmacology
September 2025
Department of Psychiatry & Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA.
Repetitive transcranial magnetic stimulation (rTMS) is an emerging treatment for neuropsychiatric disorders that shows initial efficacy, safety, and tolerability in adolescents with treatment-resistant depression. As research expands to clinical trials testing rTMS in youth with other diagnoses and at younger ages, it is important to consider how neurodevelopmental factors might moderate or mediate rTMS effects and factor this into clinical trial design. In the current paper, we review how key domains of neurodevelopment may interact with rTMS, including neuroanatomy, neural circuit network topography, neuroplasticity, hormones, state-dependent effects, and psychosocial development.
View Article and Find Full Text PDFEstimating the associations between women's maltreatment in childhood and inflammatory biomarker levels prior to and during pregnancy.
PLoS One
September 2025
Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States.
Background: Maternal childhood maltreatment has been associated with higher risk of adverse neurodevelopment in offspring. Chronic systemic inflammation has been associated with childhood maltreatment and has been identified as a gestational risk factor for adverse neurodevelopment in offspring. Thus, inflammation may be a mechanism by which maternal exposure to maltreatment affects offspring neurodevelopment.
View Article and Find Full Text PDF