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Radiation oncologists, radiopharmacists, nuclear medicine physicians, and medical oncologists have seen a renewed clinical interest in radiopharmaceuticals for the curative or the palliative treatment of cancer. To allow for the discovery and the clinical advancement of targeted radiopharmaceuticals, these stakeholders have reformed their trial efforts and remodeled their facilities to accommodate the obligations of a program centered upon radioactive investigational drug products. Now considered informally as drugs and not beam radiotherapy, radiopharmaceuticals can be more easily studied in the traditional clinical trial enterprise ranging from phase 0-I to phase III studies. Resources and physical facilities allocated to radiopharmaceuticals have brought forth new logistics and patient experience for safe and satisfactory drug delivery. The clinical use of theranostic agents-that is, diagnostic and therapeutic radionuclide pairs-has accelerated radiopharmaceutical development.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11011188 | PMC |
http://dx.doi.org/10.3390/cancers16071396 | DOI Listing |
Gates Open Res
August 2025
ideas42, New York, New York, 10004, USA.
Background: Tobacco use trends among adolescents in low- and middle-income countries, and in particular narrowing gender gaps, highlight the need for interventions to prevent and/or reduce tobacco use among adolescent girls. We evaluated a social marketing program in Ghana discouraging tobacco use among adolescent girls and additionally investigated the pathways influencing smoking behaviors to identify programmatic opportunities for impact. Leveraging the data collected through the stepped wedge cluster randomized trial and panel survey of 9000 girls aged 13-19 , we sought to apply machine learning (ML) techniques to identify the most important variables for predicting initiation of smoking.
View Article and Find Full Text PDFVaccines (Basel)
August 2025
Vaccine-Preventable Diseases Programme, World Health Organization Regional Office for Africa, Djoue, Brazzaville BP 06, Congo.
Polio supplementary immunisation activities (SIA) are implemented to rapidly increase vaccination coverage and interrupt the transmission of poliovirus in a specified geographical area. Polio SIA complements routine immunisation and is crucial for the eradication of the disease by increasing population immunity. However, several contextual factors (i.
View Article and Find Full Text PDFDiagnostics (Basel)
August 2025
Department of Obstetrics and Gynecology, Polizu Clinical Hospital, Alessandrescu-Rusescu National Institute for Mother and Child Health, 020395 Bucharest, Romania.
Cervical cancer (CC), caused mainly by high-risk human papillomavirus (hrHPV), remains a global health challenge despite being preventable. The disease's incidence and mortality rates significantly vary across regions, highlighting the need for effective screening programs. The World Health Organization prioritizes CC screening to monitor and eliminate the disease.
View Article and Find Full Text PDFBMJ Glob Health
August 2025
National Primary Healthcare Development Agency, Abuja, Nigeria.
Introduction: In May 2023, when the WHO declared that COVID-19 was no longer a public health emergency of international concern, countries began considering transitioning from the emergency phase to routine provision of COVID-19 vaccination. This paper presents the experience of seven countries with integrating COVID-19 vaccination into other health services and health system functions.
Methods: Data collection took place between August 2023 and April 2024 in Benin, Ethiopia, Ghana, India (Tamil Nadu State), Liberia, Mozambique and Nigeria using key informant interviews and focus group discussions.
New Dir Stud Leadersh
August 2025
Staley School of Leadership, Kansas State University, Manhattan, Kansas, USA.
Leadership programs establish relevance and garner public trust in higher education by demonstrating their usefulness to communities and society across sectors. In this article, the General Principles were leveraged as a tool to make sense of a pedagogy of practice applied to coursework and programs over the course of programmatic growth. This article will explore how the principles were applied to build practice orientations to knowledge.
View Article and Find Full Text PDF