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Background: The diagnosis and management of cardiomyopathies (CMs) are subject to regional variations but no study to date has systematically evaluated the clinical pathways of patients with CMs. Aims: We aimed to assess the management pathway of CM patients in Poland. Methods: This population-based cross-sectional study was conducted based on data from 2016 to 2021 obtained from the national healthcare provider using ICD10 codes to identify CM patients. The treatment pathways of CM patients, defined as the sequence of visits to the public healthcare system and categorized as urgent hospitalization (UH) for disease exacerbation, elective hospitalization (EH), tertiary outpatient medical care (TMC), primary outpatient healthcare (general practice [GP]) were analyzed. Results: Between 2016 and 2021, 65 383 CM patients were analyzed (mean age: 60 years, 65.4% men). Total healthcare services provided to these patients involved hospitalization (47.2%), TMC (16.5%), and GP (27.5%). The first registration CM diagnosis was made on an inpatient basis in 93.4% of patients (UH: 68.1%; EH: 25.1%). The mortality rate during the analyzed period was 39.8% for the total CM population, 43.9% for patients who were registered in the system only once (47% of all subjects), and 65.4% for patients with a Charlson Comorbidity Index ≥ 5. Conclusions: The diagnosis of CMs in Poland is established very late mainly during hospitalization for exacerbation of the disease. This may have an impact on the poor prognosis of CM patients especially those with a high comorbidity burden. This study highlights the urgent need for improvement in CM management in Poland.
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http://dx.doi.org/10.33963/v.phj.100178 | DOI Listing |
JCI Insight
September 2025
Edinburgh Medical School: Biomedical Sciences & Euan MacDonald Centre for M, University of Edinburgh, Edinburgh, United Kingdom.
Spinal muscular atrophy (SMA) is a neuromuscular disease caused by low levels of SMN protein. Several therapeutic approaches boosting SMN are approved for human patients, delivering remarkable improvements in lifespan and symptoms. However, emerging phenotypes, including neurodevelopmental comorbidities, are being reported in some treated SMA patients, indicative of alterations in brain development.
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September 2025
Division of Nephrology, Boston University Chobanian & Avedisian School of Medicine, Boston, United States of America.
Background: Active vitamin D metabolites, including 25-hydroxyvitamin D (25D) and 1,25-dihydroxyvitamin D (1,25D), have potent immunomodulatory effects that attenuate acute kidney injury (AKI) in animal models.
Methods: We conducted a phase 2, randomized, double-blind, multiple-dose, 3-arm clinical trial comparing oral calcifediol (25D), calcitriol (1,25D), and placebo among 150 critically ill adult patients at high-risk of moderate-to-severe AKI. The primary endpoint was a hierarchical composite of death, kidney replacement therapy (KRT), and kidney injury (baseline-adjusted mean change in serum creatinine), each assessed within 7 days following enrollment using a rank-based procedure.
Clin J Am Soc Nephrol
September 2025
University College London Great Ormond Street Hospital for Children and Institute of Child Health, London, UK.
Background: Experience with icodextrin use in children on long-term peritoneal dialysis is limited. We describe international icodextrin prescription practices and their impact on clinical outcomes: ultrafiltration, blood pressure control, residual kidney function (RKF), technique and patient survival.
Methods: We included patients under 21 years enrolled in the International Pediatric Peritoneal Dialysis Network (IPPN) between 2007 and 2024, on automated PD with a daytime dwell.
Kidney360
September 2025
Department of Pediatrics, Division of Pediatric Nephrology, Baylor College of Medicine, Houston, TX, United States.
Background: Dialysis in neonates with ESKD is often associated with multiple comorbidities and the need for more intensified dialysis regimens. With recent advances in prenatal interventions and infant specific KRT, survival of neonates with ESKD has improved over the last decade. Little is known however about the impact on the health care system of improved survival in this population.
View Article and Find Full Text PDFClin J Am Soc Nephrol
September 2025
Kidney Division, Peking University First Hospital, Peking University Institute of Nephrology; Key Laboratory of Kidney Disease, Ministry of Health of China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, China.
Background: The Therapeutic Effects of Steroids in IgA Nephropathy Global (TESTING) trial demonstrated that glucocorticoid therapy reduced proteinuria and improved kidney outcomes in patients with Immunoglobulin A Nephropathy (IgAN). Galactose-deficient IgA1 (Gd-IgA1) plays a central role in IgAN pathogenesis by promoting immune complex formation. However, the effects of glucocorticoid on pathogenic IgA levels remain unclear.
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