98%
921
2 minutes
20
Ground reaction forces (GRFs) are essential for the analysis of human movement. To measure GRFs, 3D force plates that are fixed to the floor are used with large measuring ranges, excellent accuracy and high sample frequency. For less dynamic movements, like walking or squatting, portable 3D force plates are used, while if just the vertical component of the GRFs is of interest, pressure plates or in-shoe pressure measurements are often preferred. In many cases, however, it is impossible to measure 3D GRFs, e.g., during athletic competitions, at work or everyday life. It is still challenging to predict the horizontal components of the GRFs from kinematics using biomechanical models. The virtual pivot point (VPP) concept states that measured GRFs during walking intercept in a point located above the center of mass, while during running, the GRFs cross each other at a point below the center of mass. In the present study, this concept is used to compare predicted GRFs from measured kinematics with measured 3D-GRFs, not only during walking but also during more static movements like squatting and inline lunge. To predict the GRFs a full-body biomechanical model was used while gradually changing the positions of the VPP. It is shown that an optimal VPP improves the prediction of GRFs not only for walking but also for inline lunge and squats.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11002124 | PMC |
http://dx.doi.org/10.3389/fbioe.2024.1286644 | DOI Listing |
Foot Ankle Int
September 2025
Department of Radiology, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan.
Background: Coronal wedge insoles are commonly prescribed to mitigate musculoskeletal disorders, yet their static-standing kinematic and kinetic effects on lower extremity joints remain insufficiently understood.
Methods: This cross-sectional experimental study included 15 healthy older adults (mean 64.9 ± 6.
Front Immunol
September 2025
School of Medicine, Nankai University, Tianjin, China.
Purpose: Relapse remains the leading cause of treatment failure in high-risk acute myeloid leukemia (AML) or myelodysplastic syndrome-IB (MDS-IB) patients after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Ruxolitinib has demonstrated antileukemic activity , and decitabine has been found to be tolerable when combined with modified busulfan-cyclophosphamide (mBu/Cy) conditioning regimen. Here, we investigated the efficacy of ruxolitinib and decitabine plus a mBu/Cy conditioning regimen (Rux-Dec-mBu/Cy) in reducing relapse in high-risk AML/MDS patients ().
View Article and Find Full Text PDFJ Exp Bot
September 2025
Department of Biology, Kyungpook National University, Daegu 41566, Korea.
Above-ground lateral organs, such as leaves and flowers, should grow to an optimal size and develop particular structures, which are primarily laid out on the meristematic activities of their primordia. The GROWTH-REGULATING FACTOR‒GRF-INTERACTING FACTOR (GRF‒GIF) transcriptional complex and the AINTEGUMENTA (ANT) transcription factor play key roles in the establishment of the meristematic competence of lateral organ primordia with highly overlapping expression patterns, and thus functional relationships between them have long been speculated. In this study, we constructed the ant gif1 gif2 gif3 quadruple mutant, which produced much smaller and narrower leaves, sepals, and petals with far fewer cells compared with its parental lines.
View Article and Find Full Text PDFFront Immunol
September 2025
Haematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Background: The introduction of posttransplant cyclophosphamide (PTCy) is one of the major achievements in the field of haploidentical stem cell transplantation (haplo-HCT). The transplant conditioning intensity (TCI) score is a refined classification of conditioning regimens that assigns weight scores to conditioning regimen components. The aim of our analysis was twofold: to assess the effect on transplant outcomes of combining PTCy with calcineurin inhibitor + mycophenolate mofetil (MMF) instead of mTOR inhibitor + MMF for GvHD prophylaxis, and to assess the effect of stratification by conditioning intensity in the setting of haplo-HCT.
View Article and Find Full Text PDFJ Biomech
October 2025
Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, 46556, IN, United States of America.
The whole-body center of mass (CoM) plays an important role in quantifying human movement. Prediction of future CoM trajectory, modeled as a point mass under influence of external forces, can be a surrogate for inferring intent. Given the current CoM position and velocity, predicting the future CoM position by forward integration requires a forecast of CoM accelerations during the prediction horizon.
View Article and Find Full Text PDF