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Introduction: Glass-ionomer (GIC) cement was introduced in 1972 as a "new filling material of dentistry". It is bioactive and plays an important role in caries prevention due to its ability to release fluoride into the oral environment and remineralization of dental hard tissues. However, its properties such as moisture sensitivity, wear resistance, and bond strength are not sufficient to inflict the antimicrobial environment. This study aimed to evaluate the antibacterial property of four different GIC cements against S. mutans and L. acidophilus.
Methodology: This study was conducted on 120 disk-shaped samples (30 for antibacterial activity), which were placed in Petri dishes holding Müeller Hinton agar. Bacterial strains were overhauled in the brain heart infusion culture medium, and by utilizing disposable straps on blood agar medium, 100 ml of the strain inoculum was plated out. Through the diffusion method on the solid medium, the antibacterial activity of GIC was determined.
Results: The antibacterial activity was the highest for Riva silver and chemifill rock for 24 and 72 hours, respectively. For 48 hours, Equia forte and chemifill rock had the highest antibacterial activity, and there was a significant difference between the groups.
Conclusion: Ketac™ molar easymix inhibited the growth of S. mutans and L. acidophilus but had the lowest antibacterial effect compared to other GICs.
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http://dx.doi.org/10.4103/jpbs.jpbs_450_23 | DOI Listing |
Mem Inst Oswaldo Cruz
September 2025
Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Laboratório Interdisciplinar de Pesquisas Médicas, Rio de Janeiro, RJ, Brasil.
Background: Parasite antigens and plasma lipopolysaccharide (LPS) levels from luminal origin in visceral leishmaniasis (VL) patients are correlated with cellular activation and low CD4+T cell counts.
Objectives: Our aim was to verify whether Leishmania infantum infection damages the intestinal barrier and whether combination antimonial/antibiotic contributes to the reduction of LPS levels and immune activation.
Methods: Golden hamsters were grouped in: G1-uninfected; G2-infected with L.
Langmuir
September 2025
Department of Light Chemical Engineering, School of Textiles Science and Engineering; Key Laboratory of Special Protective, Ministry of Education; Jiangnan University, Wuxi 214122, P. R. China.
Polymerizable deep eutectic solvents (PDES) have recently emerged as a class of solvent-free ionically conductive elastomers and are considered among the most feasible candidates for next-generation ionotronic devices. However, the fundamental challenge persists in synergistically combining high mechanical strength, robust adhesion, reliable self-healing capacity, and effective antimicrobial performance within a unified material system capable of fulfilling the rigorous operational demands of next-generation ionotronic devices across multifunctional applications. Inspired by the hierarchical structure of spider silk, HCAG eutectogels composed of acrylic acid (AA), 2-hydroxyethyl acrylate (HEA), and choline chloride (ChCl) were successfully synthesized via a one-step photopolymerization method.
View Article and Find Full Text PDFBiomater Sci
September 2025
School of Biomedical Sciences, Kent State University, Kent, OH 44242, USA.
Copper ions have been considered to hold promise for the treatment of wound infections due to their unique characteristics that exhibit not only antibacterial activities through multiple bactericidal mechanisms but also tissue reparative activities by acting as a co-factor for many angiogenic promoters and enzymes. However, higher doses are necessary to achieve sufficient bactericidal and antibiofilm effects. The objective of this study is to develop copper nanoparticles (CuNPs) as an antimicrobial agent by harnessing the characteristics of copper and vitamin C (VC) to form a sustained catalytic cycle, leading to a significant enhancement of bactericidal and antibiofilm effects when compared with the use of CuNPs alone.
View Article and Find Full Text PDFLasers Med Sci
September 2025
Laser Research Center of Dentistry, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Microbial contamination of absorbable collagen membranes used in guided bone regeneration (GBR) may compromise healing outcomes. This study aimed to investigate whether the minimum inhibitory concentration (MIC) of hydrogen peroxide (HO) can improve the antibacterial effect of indocyanine green (ICG)-mediated antimicrobial photodynamic therapy (PDT) on absorbable collagen membranes while reducing the need for high HO concentrations. A laboratory-based model was developed using Streptococcus sanguinis and Staphylococcus aureus.
View Article and Find Full Text PDFFEMS Microbiol Lett
September 2025
Protein Technology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Arthrospira platensis (Spirulina) is one the highly valuable cyanobacteria in food and pharmaceutical industry. The intracellular and extracellular polysaccharide (PS) extracts of A. platensis have been exhibited different biological functions.
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