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Article Abstract
Aim: The aim of this study was to investigate the metabolism of in human, pig, goat and rat liver microsomes and to elucidate the metabolic pathways and cleavage patterns of the Gelsemium alkaloids among different species.
Methods: A human, goat, pig and rat liver microsomes were incubated . After incubating at 37°C for 1 hour and centrifuging, the processed samples were detected by was used to detect alcohol extract of and its metabolites.
Results: Forty-six natural products were characterized from alcohol extract of Gelsemium elegans and 13 metabolites were identified. These 13 metabolites belong to the gelsemine, koumine, gelsedine, humantenine, yohimbane, and sarpagine classes of alkaloids. The metabolic pathways included oxidation, demethylation and dehydrogenation. After preliminary identification, the metabolites detected in the four species were different. All 13 metabolites were detected in pig and rat microsomes, but no oxidative metabolites of Gelsedine-type alkaloids were detected in goat and human microsomes.
Conclusion: In this study, metabolic patterns in different species are clarified and the metabolism of is investigated. It is of great significance for its clinical development and rational application.
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| http://dx.doi.org/10.2174/0113892002298633240322071126 | DOI Listing |
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