Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
BACE1 is well-known for its role in the development of Alzheimer's disease. Recent publications, including our own, have demonstrated a role for this enzyme in other chronic diseases. The aim of this study was to investigate the role of BACE1 in the autoimmune disease systemic sclerosis (SSc). BACE1 protein levels were elevated in the skin of patients with SSc. Inhibition of BACE1 with small-molecule inhibitors or small interfering RNA blocked SSc and fibrotic stimuli-mediated fibroblast activation. Furthermore, we show that BACE1 regulation of dermal fibroblast activation is dependent on β-catenin and Notch signaling. The neurotropic factor brain-derived neurotrophic factor negatively regulates BACE1 expression and activity in dermal fibroblasts. Finally, sera from patients with SSc show higher β-amyloid and lower brain-derived neurotrophic factor levels than healthy controls. The ability of BACE1 to regulate SSc fibroblast activation reveals a therapeutic target in SSc. Several BACE1 inhibitors have been shown to be safe in clinical trials for Alzheimer's disease and could be repurposed to ameliorate fibrosis progression.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jid.2024.03.024 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Protein intake counteracts alcohol intake in the regulation of postprandial FGF21 secretion in humans.
Am J Physiol Endocrinol Metab
September 2025
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
FGF21 is a hormone secreted from the liver in response to various nutritional stressors, suggested to be acting to balance dietary intake through negative feedback regulation. This meal study aimed to investigate two different potential nutrient interactions on postprandial FGF21 secretion in healthy human participants: 1) between intake of alcohol and protein and 2) between intake of alcohol and vitamin A (retinol). In a 4-arm, randomized, double-blinded, cross-over meal study (NCT06105476), postprandial circulating concentrations of FGF21, glucose, insulin, ethanol, and acetate were compared after intake of four different test drinks containing alcohol, alcohol+protein, alcohol+retinol or retinol in 27 healthy humans.
View Article and Find Full Text PDF[Therapeutic advances in metabolic dysfunction-associated steatotic liver disease].
Rev Med Suisse
August 2025
Service de gastroentérologie et d'hépatologie, Département de médecine, Hôpitaux universitaires de Genève, 1211 Genève 14.
The treatment of metabolic dysfunction-associated steatotic liver disease involves physical activity, weight loss, and management of comorbidities (diabetes, hypertension, dyslipidemia). In 2024, the American Food and Drug Administration provisionally approved resmetirom for metabolic dysfunction-associated steatohepatitis. Other promising molecules are being evaluated (glucagon-like peptide 1 receptor agonists, fibroblast growth factor 21 agonist).
View Article and Find Full Text PDFBlackcurrant polyphenol extract improves alcoholic liver disease through the FGF21-NET/c-FOS pathway.
Food Funct
September 2025
College of Food Science, Shenyang Agricultural University, Shenyang, Liaoning, China.
Blackcurrant is rich in polyphenolic substances with corresponding antioxidant and anti-inflammatory properties. Therefore, based on the identification of typical functional components of blackcurrant polyphenols (BCP), the present study investigated the therapeutic effects of BCP on alcoholic liver disease (ALD) by modulating fibroblast growth factor 21 (FGF21) in both an HepG2 cell model and an C57BL/6J mouse model of acute alcoholism. In total, 892 polyphenols and 45 anthocyanins were identified in blackcurrant.
View Article and Find Full Text PDFCitric acid-modified chitosan hydrogel loaded with shikonin promotes skin wound healing.
J Burn Care Res
September 2025
Shanghai Starriver Bilingual School, Shanghai, China.
Background: Despite the advancements of pharmacological treatments and gauze dressings in the field of skin wound healing, these methods present numerous limitations. Therefore, developing a multifunctional material capable of efficiently promoting skin wound healing is particularly crucial.
Methods: Citric acid (CA)-modified chitosan (CS) loaded with Shikonin (SK) (CA-CS-SK) hydrogel was prepared via the freeze-thaw method.
Heterogeneous zinc/catechol-derived resin microsphere-functionalized composite hydrogels with antibacterial and anti-inflammatory activities promote bacterial-infected wound healing.
Regen Biomater
August 2025
College of Textiles & Clothing, Institute of Functional Textiles and Advanced Materials, Qingdao 266071, China.
Bacterial infection in the injured skin may threaten the wound repair and skin regeneration owing to aggravated inflammation. The multifunctional dressings with persistent antibacterial activity and improved anti-inflammatory capability are urgently required. Herein, a type of heterogeneous zinc/catechol-derived resin microspheres (Zn/CFRs) composed of zinc ions (Zn) and zinc oxide (ZnO) nanoparticles was developed to impart the methacrylamide chitosan (CSMA)-oxidized hyaluronic acid (OHA) hydrogel with a persistent Zn release behavior.
View Article and Find Full Text PDF