Pneumonia Caused by and SARS-CoV-2 Coinfection Diagnosed Using Metagenomic Next-Generation Sequencing: A Case Report.

Int Med Case Rep J

Department of Respiratory and Critical Care Medicine, Zhongshan People's Hospital, Zhongshan, Guangdong Province, People's Republic of China.

Published: March 2024


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

We report a case of pneumonia caused by coinfection with and the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron XBB.1 variant, confirmed using metagenomic next-generation sequencing (mNGS) and quantitative polymerase chain reaction (qPCR). and SARS-CoV-2 were detected in bronchoalveolar lavage fluid using mNGS. Additionally, mNGS detected in blood and nasopharyngeal specimens and was more sensitive than qPCR. The patient recovered after treatment with moxifloxacin. This report highlights the use of coinfections of and SARS-CoV-2, as mNGS has already been recognized to be a diagnostic tool for identifying coinfections.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10962458PMC
http://dx.doi.org/10.2147/IMCRJ.S458131DOI Listing

Publication Analysis

Top Keywords

pneumonia caused
8
metagenomic next-generation
8
next-generation sequencing
8
sars-cov-2
4
caused sars-cov-2
4
sars-cov-2 coinfection
4
coinfection diagnosed
4
diagnosed metagenomic
4
sequencing case
4
case report
4

Similar Publications

We report the case of a 3-month-old infant with methicillin-resistant Staphylococcus aureus (MRSA) necrotizing fasciitis of the neck and chest complicated by bacteremia, pneumonia, and mediastinitis, which required multiple surgical debridements, including median sternotomy. The case is unsual given the patient's age and causative pathogen, and underscores the importance of early diagnosis, timely surgical intervention, and multidisciplinary collaboration to ensure survival.

View Article and Find Full Text PDF

Objective: Although existing evidence suggests a potential link between dementia and adverse outcomes in patients with COVID-19, a definitive relationship is uncertain. This study aimed to evaluate the impact of dementia on in-hospital outcomes of patients in the presence of COVID-19.

Methods: The US Nationwide Inpatient Sample (NIS) was searched for patients 65 years or older hospitalised for COVID-19 in 2020.

View Article and Find Full Text PDF

This study presents a rare case of severe acute bacterial skin and soft tissue infection (ABSSSI) following freshwater fish spike injury in a 73-year-old man. Within 24 hours of sustaining the wound, the patient developed septic shock and progressive necrotizing fasciitis. Despite early administration of broad-spectrum antibiotics and intensive care, his condition deteriorated, necessitating below-the-elbow amputation on hospital day four.

View Article and Find Full Text PDF

Background Diabetes mellitus is a global public health challenge, significantly increasing susceptibility to infections, particularly urinary tract infections (UTIs). Diabetic patients face a higher risk of recurrent and complicated UTIs due to impaired immune function, poor glycemic control, and associated comorbidities. Objective This study aimed to determine the frequency and demographic trends of hospital admissions in diabetic patients suffering from urinary tract infections, identify associated clinical risk factors, evaluate the microbiological profile of uropathogens, and assess prevailing patterns of antimicrobial resistance.

View Article and Find Full Text PDF

Community-acquired pneumonia (CAP) is a significant cause of morbidity and mortality in adults. National guidelines by the British Thoracic Society (BTS) and the National Institute for Health and Care Excellence (NICE) recommend follow-up chest imaging within six weeks for adults diagnosed with CAP to exclude underlying malignancy. Timely follow-up of radiological abnormalities in CAP is crucial, as infectious infiltrates can obscure early signs of malignancy.

View Article and Find Full Text PDF