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We report the case of a 3-month-old infant with methicillin-resistant Staphylococcus aureus (MRSA) necrotizing fasciitis of the neck and chest complicated by bacteremia, pneumonia, and mediastinitis, which required multiple surgical debridements, including median sternotomy. The case is unsual given the patient's age and causative pathogen, and underscores the importance of early diagnosis, timely surgical intervention, and multidisciplinary collaboration to ensure survival.
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http://dx.doi.org/10.1002/lary.70114 | DOI Listing |
Laryngoscope
September 2025
Department of Otolaryngology-Head and Neck Surgery, New York-Presbyterian/Weill Cornell Medical Center, New York, New York, USA.
We report the case of a 3-month-old infant with methicillin-resistant Staphylococcus aureus (MRSA) necrotizing fasciitis of the neck and chest complicated by bacteremia, pneumonia, and mediastinitis, which required multiple surgical debridements, including median sternotomy. The case is unsual given the patient's age and causative pathogen, and underscores the importance of early diagnosis, timely surgical intervention, and multidisciplinary collaboration to ensure survival.
View Article and Find Full Text PDFFront Microbiol
August 2025
Department of Laboratory Medicine, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Background: Extracellular vesicles (EVs) derived from () carry multiple components, such as toxins, antigens, and resistance determinants, whose production is influenced by exposure to β-lactam antibiotics. However, systematic studies on the effects of β-lactam antibiotics on the release and functions of EVs remain limited.
Methods: Extracellular vesicles (EVs) were isolated from the OS-MRSA (OS-200) strain by ultracentrifugation, including both EVs untreated with antibiotics and those exposed to sub-inhibitory concentrations of oxacillin (OI-EVs).
Open Forum Infect Dis
August 2025
Department of Pharmacy Services, Penn Presbyterian Medical Center, Philadelphia, Pennsylvania, USA.
Background: Injection drug use (IDU) containing xylazine has been associated with the development of chronic necrotic wounds, albeit not all are of infectious etiology. This study describes the clinical microbiology of xylazine-associated wound infections to guide antimicrobial prescribing.
Methods: We conducted a retrospective, single-center cohort study of adults hospitalized with xylazine-associated wound infections related to IDU from 1 April 2022 to 1 December 2023.
Pneumologie
August 2025
Klinik für Pneumologie und Beatmungsmedizin, Klinikum Stuttgart Katharinenhospital, Stuttgart, Germany.
Panton-Valentine leukocidin (PVL) is a toxine which forms a pore-forming heptamer on neutrophil membrandes leading to neutrophil lysis. Invasive community-onset PVL producing staphylococcus aureus (S. aureus) induced diseases have emerged worldwide, but incidence vary and is strongly attributed to strain types and lineages.
View Article and Find Full Text PDFJMA J
July 2025
Department of Internal Medicine, Self-Defense Forces Central Hospital, Tokyo, Japan.