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Automatically and accurately segmenting skin lesions can be challenging, due to factors such as low contrast and fuzzy boundaries. This paper proposes a hybrid encoder-decoder model (CTH-Net) based on convolutional neural network (CNN) and Transformer, capitalizing on the advantages of these approaches. We propose three modules for skin lesion segmentation and seamlessly connect them with carefully designed model architecture. Better segmentation performance is achieved by introducing SoftPool in the CNN branch and sandglass block in the bottleneck layer. Extensive experiments were conducted on four publicly accessible skin lesion datasets, ISIC 2016, ISIC 2017, ISIC 2018, and PH to confirm the efficacy and benefits of the proposed strategy. Experimental results show that the proposed CTH-Net provides better skin lesion segmentation performance in both quantitative and qualitative testing when compared with state-of-the-art approaches. We believe the CTH-Net design is inspiring and can be extended to other applications/frameworks.
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http://dx.doi.org/10.1016/j.isci.2024.109442 | DOI Listing |
J Korean Med Sci
September 2025
Department of Transdisciplinary Medicine, Seoul National University Hospital, Seoul, Korea.
Background: With the increasing incidence of skin cancer, the workload for pathologists has surged. The diagnosis of skin samples, especially for complex lesions such as malignant melanomas and melanocytic lesions, has shown higher diagnostic variability compared to other organ samples. Consequently, artificial intelligence (AI)-based diagnostic assistance programs are increasingly needed to support dermatopathologists in achieving more consistent diagnoses.
View Article and Find Full Text PDFDermatol Reports
September 2025
Clinical Dermatology Unit, San Gallicano Dermatological Institute IRCCS, Rome.
Psoriasis is a dermatological disorder whose clinical manifestations have attracted the interest of physicians since ancient times. Hippocrates of Cos in the 5th century B.C.
View Article and Find Full Text PDFAm J Case Rep
September 2025
Center of Laboratory Medicine, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.
BACKGROUND Mycophenolate mofetil (MMF) is a disease-modifying antirheumatic drug (DMARD) that has been reported to cause skin rashes. Systemic lupus erythematosus (SLE) is also associated with typical discoid skin lesions. This report describes the case of a 50-year-old woman with a 6-year history of SLE presenting with a 6-day history of fever and skin rash after starting treatment with MMF.
View Article and Find Full Text PDFMedicine (Baltimore)
September 2025
Al Mouwasat University Hospital, Damascus University, Damascus, Syria.
Rationale: Systemic sclerosis (SS) is an immune-mediated connective disease characterized by skin fibrosis, microvascular damage, and multisystem manifestations. One of the most important processes in connective tissue disorders is vasculitis. The clinical findings can differ when the disease is presented with an antineutrophil cytoplasmic antibody.
View Article and Find Full Text PDFPediatr Dermatol
September 2025
Division of Dermatology, David Geffen School of Medicine at the University of California, Los Angeles, California, USA.